Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention

Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention

Aldehyde dehydrogenase 2 (ALDH2) has both dehydrogenase and esterase activity; its dehydrogenase activity is closely related to the metabolism of aldehydes produced under oxidative stress (OS). In this review, we recapitulate the enzyme activity of ALDH2 in combination with its protein structure, su...

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Bibliographic Details
Main Authors:	Jie Gao, Yue Hao, Xiangshu Piao, Xianhong Gu
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	International Journal of Molecular Sciences
Subjects:	aldehyde dehydrogenase 2 (ALDH2) post-translational modifications (PTMs) oxidative stress-related diseases 4-hydroxy-2-nonenal (4-HNE)
Online Access:	https://www.mdpi.com/1422-0067/23/5/2682

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