Local and systemic oxidative stress in chronic suppurative otitis media

Introduction. According to the literature, oxidative stress is described as one of the main factors in the pathogenesis of chronic suppurative otitis media, supporting the inflammatory process at the local level. The transition of inflammatory mediators to the systemic level is associated with the r...

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Main Authors: I. D. Dubinets, M. Yu. Korkmazov, A. I. Sinitskii, E. I. Danshova, I. N. Skirpichnikov, M. V. Mokina, D. M. Mirzagaliev
Format: Article
Language:Russian
Published: Remedium Group LLC 2021-12-01
Series:Медицинский совет
Subjects:
Online Access:https://www.med-sovet.pro/jour/article/view/6564
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author I. D. Dubinets
M. Yu. Korkmazov
A. I. Sinitskii
E. I. Danshova
I. N. Skirpichnikov
M. V. Mokina
D. M. Mirzagaliev
author_facet I. D. Dubinets
M. Yu. Korkmazov
A. I. Sinitskii
E. I. Danshova
I. N. Skirpichnikov
M. V. Mokina
D. M. Mirzagaliev
author_sort I. D. Dubinets
collection DOAJ
description Introduction. According to the literature, oxidative stress is described as one of the main factors in the pathogenesis of chronic suppurative otitis media, supporting the inflammatory process at the local level. The transition of inflammatory mediators to the systemic level is associated with the risk of developing ear purulent-destructive complications. The study of the products of lipid peroxidation in comparison with morphological changes in the structures of the temporal bone will justify the tactics of the operation.Aim. Comparison of the levels of lipid peroxidation products at the local and systemic levels in chronic suppurative otitis media, depending on the nature of pathomorphological changes in the structures of the temporal bone.Materials and methods. A prospective study of 130 patients with chronic suppurative otitis media at the age of 20-62 years with a verified diagnosis of chronic suppurative otitis media, admitted for surgical treatment, was carried out. To study the indicators of oxidative stress at the systemic level, the blood serum of patients was used; at the local level, the bone biomaterial obtained from patients during the surgical treatment of chronic suppurative otitis media was used. The quantitative determination of the primary, secondary and final products of peroxidation was carried out in the groups of patients with separate registration of lipoperoxides in the heptane and isopropanol phases of the lipid extract by spectrophotometry.Results and discussion. In the observation of patients with morphological signs of purulent destruction of the temporal bone, not only a local level of inflammation activity, but also a systemic level of an unfavorable outcome was revealed in two variants: osteoproliferation or osteonecrosis of the bone tissue of the temporal bone in chronic purulent otitis media with a constant threat to the patient's life due to intracranial purulent complications.Conclusion. The appearance in low concentrations of lipid peroxidation products in serum in patients with chronic purulent otitis media substantiates the need for a behind-the-ear approach in reconstructive-sanitizing otosurgery even with minimal clinical manifestations and CT scan data, since at the preclinical level it confirms the osteonecrotic type of bone remodeling with the risk of delayed death.
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spelling doaj.art-24aa63b30c6147f799e21e5cd9b7bbd02023-04-23T06:56:47ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902021-12-0101814815610.21518/2079-701X-2021-18-148-1565927Local and systemic oxidative stress in chronic suppurative otitis mediaI. D. Dubinets0M. Yu. Korkmazov1A. I. Sinitskii2E. I. Danshova3I. N. Skirpichnikov4M. V. Mokina5D. M. Mirzagaliev6South Ural State Medical UniversitySouth Ural State Medical UniversitySouth Ural State Medical UniversityRegional Clinical Hospital No. 8Chelyabinsk Regional Clinical HospitalCity Clinical Hospital No. 6South Ural State Medical UniversityIntroduction. According to the literature, oxidative stress is described as one of the main factors in the pathogenesis of chronic suppurative otitis media, supporting the inflammatory process at the local level. The transition of inflammatory mediators to the systemic level is associated with the risk of developing ear purulent-destructive complications. The study of the products of lipid peroxidation in comparison with morphological changes in the structures of the temporal bone will justify the tactics of the operation.Aim. Comparison of the levels of lipid peroxidation products at the local and systemic levels in chronic suppurative otitis media, depending on the nature of pathomorphological changes in the structures of the temporal bone.Materials and methods. A prospective study of 130 patients with chronic suppurative otitis media at the age of 20-62 years with a verified diagnosis of chronic suppurative otitis media, admitted for surgical treatment, was carried out. To study the indicators of oxidative stress at the systemic level, the blood serum of patients was used; at the local level, the bone biomaterial obtained from patients during the surgical treatment of chronic suppurative otitis media was used. The quantitative determination of the primary, secondary and final products of peroxidation was carried out in the groups of patients with separate registration of lipoperoxides in the heptane and isopropanol phases of the lipid extract by spectrophotometry.Results and discussion. In the observation of patients with morphological signs of purulent destruction of the temporal bone, not only a local level of inflammation activity, but also a systemic level of an unfavorable outcome was revealed in two variants: osteoproliferation or osteonecrosis of the bone tissue of the temporal bone in chronic purulent otitis media with a constant threat to the patient's life due to intracranial purulent complications.Conclusion. The appearance in low concentrations of lipid peroxidation products in serum in patients with chronic purulent otitis media substantiates the need for a behind-the-ear approach in reconstructive-sanitizing otosurgery even with minimal clinical manifestations and CT scan data, since at the preclinical level it confirms the osteonecrotic type of bone remodeling with the risk of delayed death.https://www.med-sovet.pro/jour/article/view/6564chronic suppurative otitis mediareconstructive and sanitizing otosurgerybone tissueserumspectrophotomerismoxidative stress
spellingShingle I. D. Dubinets
M. Yu. Korkmazov
A. I. Sinitskii
E. I. Danshova
I. N. Skirpichnikov
M. V. Mokina
D. M. Mirzagaliev
Local and systemic oxidative stress in chronic suppurative otitis media
Медицинский совет
chronic suppurative otitis media
reconstructive and sanitizing otosurgery
bone tissue
serum
spectrophotomerism
oxidative stress
title Local and systemic oxidative stress in chronic suppurative otitis media
title_full Local and systemic oxidative stress in chronic suppurative otitis media
title_fullStr Local and systemic oxidative stress in chronic suppurative otitis media
title_full_unstemmed Local and systemic oxidative stress in chronic suppurative otitis media
title_short Local and systemic oxidative stress in chronic suppurative otitis media
title_sort local and systemic oxidative stress in chronic suppurative otitis media
topic chronic suppurative otitis media
reconstructive and sanitizing otosurgery
bone tissue
serum
spectrophotomerism
oxidative stress
url https://www.med-sovet.pro/jour/article/view/6564
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