Targeting microRNAs with thymoquinone: a new approach for cancer therapy
Abstract Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-021-00286-5 |
| _version_ | 1818606524269854720 |
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| author | Mina Homayoonfal Zatollah Asemi Bahman Yousefi |
| author_facet | Mina Homayoonfal Zatollah Asemi Bahman Yousefi |
| author_sort | Mina Homayoonfal |
| collection | DOAJ |
| description | Abstract Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it is one of the overriding priorities of world health. Recently, bioactive natural compounds have been widely recognized due to their therapeutic effects for treatment of various chronic disorders, notably cancer. Thymoquinone (TQ), the most valuable constituent of black cumin seeds, has shown anti-cancer characteristics in a wide range of animal models. The revolutionary findings have revealed TQ’s ability to regulate microRNA (miRNA) expression, offering a promising approach for cancer therapy. MiRNAs are small noncoding RNAs that modulate gene expression by means of variation in features of mRNA. MiRNAs manage several biological processes including gene expression and cellular signaling pathways. Accordingly, miRNAs can be considered as hallmarks for cancer diagnosis, prognosis and therapy. The purpose of this study was to review the various molecular mechanisms by which TQ exerts its potential as an anti-cancer agent through modulating miRNAs. |
| first_indexed | 2024-12-16T14:12:13Z |
| format | Article |
| id | doaj.art-24ac7b03845b4d78bd2568b64a2ee4b1 |
| institution | Directory Open Access Journal |
| issn | 1425-8153 1689-1392 |
| language | English |
| last_indexed | 2024-12-16T14:12:13Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-24ac7b03845b4d78bd2568b64a2ee4b12022-12-21T22:28:43ZengBMCCellular & Molecular Biology Letters1425-81531689-13922021-10-0126112210.1186/s11658-021-00286-5Targeting microRNAs with thymoquinone: a new approach for cancer therapyMina Homayoonfal0Zatollah Asemi1Bahman Yousefi2Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical SciencesMolecular Medicine Research Center, Tabriz University of Medical SciencesAbstract Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it is one of the overriding priorities of world health. Recently, bioactive natural compounds have been widely recognized due to their therapeutic effects for treatment of various chronic disorders, notably cancer. Thymoquinone (TQ), the most valuable constituent of black cumin seeds, has shown anti-cancer characteristics in a wide range of animal models. The revolutionary findings have revealed TQ’s ability to regulate microRNA (miRNA) expression, offering a promising approach for cancer therapy. MiRNAs are small noncoding RNAs that modulate gene expression by means of variation in features of mRNA. MiRNAs manage several biological processes including gene expression and cellular signaling pathways. Accordingly, miRNAs can be considered as hallmarks for cancer diagnosis, prognosis and therapy. The purpose of this study was to review the various molecular mechanisms by which TQ exerts its potential as an anti-cancer agent through modulating miRNAs.https://doi.org/10.1186/s11658-021-00286-5ThymoquinonemiRNASignaling pathwayMetastasisAngiogenesisApoptosis |
| spellingShingle | Mina Homayoonfal Zatollah Asemi Bahman Yousefi Targeting microRNAs with thymoquinone: a new approach for cancer therapy Cellular & Molecular Biology Letters Thymoquinone miRNA Signaling pathway Metastasis Angiogenesis Apoptosis |
| title | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
| title_full | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
| title_fullStr | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
| title_full_unstemmed | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
| title_short | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
| title_sort | targeting micrornas with thymoquinone a new approach for cancer therapy |
| topic | Thymoquinone miRNA Signaling pathway Metastasis Angiogenesis Apoptosis |
| url | https://doi.org/10.1186/s11658-021-00286-5 |
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