Innovative Biomaterials for the Treatment of Bone Cancer
Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients’ survival and ameli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/15/8214 |
| _version_ | 1797525497657163776 |
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| author | Luca Ambrosio Maria Grazia Raucci Gianluca Vadalà Luigi Ambrosio Rocco Papalia Vincenzo Denaro |
| author_facet | Luca Ambrosio Maria Grazia Raucci Gianluca Vadalà Luigi Ambrosio Rocco Papalia Vincenzo Denaro |
| author_sort | Luca Ambrosio |
| collection | DOAJ |
| description | Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients’ survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop innovative biomaterials able to selectively inhibit bone cancer progression while reducing the loss of bone structural properties secondary to local tissue invasion. In this review, we describe the state of the art of innovative biomaterials for the treatment of bone cancer. Along with physiological bone remodeling, the development of bone metastasis and osteosarcoma will be depicted. Subsequently, recent advances on nanocarrier-based drug delivery systems, as well as the application of novel, multifunctional biomaterials for the treatment of bone cancer will be discussed. Eventually, actual limitations and promising future perspectives regarding the employment of such approaches in the clinical scenario will be debated. |
| first_indexed | 2024-03-10T09:13:43Z |
| format | Article |
| id | doaj.art-24ae94298c6947c0be9f6e5731cd7a28 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:13:43Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-24ae94298c6947c0be9f6e5731cd7a282023-11-22T05:45:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012215821410.3390/ijms22158214Innovative Biomaterials for the Treatment of Bone CancerLuca Ambrosio0Maria Grazia Raucci1Gianluca Vadalà2Luigi Ambrosio3Rocco Papalia4Vincenzo Denaro5Laboratory of Regenerative Orthopaedics, Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyInstitute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54, Mostra d’Oltremare Pad. 20, 80125 Naples, ItalyLaboratory of Regenerative Orthopaedics, Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyInstitute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54, Mostra d’Oltremare Pad. 20, 80125 Naples, ItalyLaboratory of Regenerative Orthopaedics, Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyLaboratory of Regenerative Orthopaedics, Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico, University of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyBone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients’ survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop innovative biomaterials able to selectively inhibit bone cancer progression while reducing the loss of bone structural properties secondary to local tissue invasion. In this review, we describe the state of the art of innovative biomaterials for the treatment of bone cancer. Along with physiological bone remodeling, the development of bone metastasis and osteosarcoma will be depicted. Subsequently, recent advances on nanocarrier-based drug delivery systems, as well as the application of novel, multifunctional biomaterials for the treatment of bone cancer will be discussed. Eventually, actual limitations and promising future perspectives regarding the employment of such approaches in the clinical scenario will be debated.https://www.mdpi.com/1422-0067/22/15/8214bone metastasisosteosarcomabiomaterialsnanocarriersmusculoskeletal oncologytissue engineering |
| spellingShingle | Luca Ambrosio Maria Grazia Raucci Gianluca Vadalà Luigi Ambrosio Rocco Papalia Vincenzo Denaro Innovative Biomaterials for the Treatment of Bone Cancer International Journal of Molecular Sciences bone metastasis osteosarcoma biomaterials nanocarriers musculoskeletal oncology tissue engineering |
| title | Innovative Biomaterials for the Treatment of Bone Cancer |
| title_full | Innovative Biomaterials for the Treatment of Bone Cancer |
| title_fullStr | Innovative Biomaterials for the Treatment of Bone Cancer |
| title_full_unstemmed | Innovative Biomaterials for the Treatment of Bone Cancer |
| title_short | Innovative Biomaterials for the Treatment of Bone Cancer |
| title_sort | innovative biomaterials for the treatment of bone cancer |
| topic | bone metastasis osteosarcoma biomaterials nanocarriers musculoskeletal oncology tissue engineering |
| url | https://www.mdpi.com/1422-0067/22/15/8214 |
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