SNARE proteins rescue impaired autophagic flux in Down syndrome.

SNARE proteins rescue impaired autophagic flux in Down syndrome.

Down syndrome (DS) is a chromosomal disorder caused by trisomy of chromosome 21 (Ts21). Unbalanced karyotypes can lead to dysfunction of the proteostasis network (PN) and disrupted proteostasis is mechanistically associated with multiple DS comorbidities. Autophagy is a critical component of the PN...

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Main Authors: Stefanos Aivazidis, Abhilasha Jain, Abhishek K Rauniyar, Colin C Anderson, John O Marentette, David J Orlicky, Kristofer S Fritz, Peter S Harris, David Siegel, Kenneth N Maclean, James R Roede
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223254

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