Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases
The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation in vital biochemical reactions, influencing DNA methyla...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1322419/full |
| _version_ | 1797366711654023168 |
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| author | Ayman Bou Ghanem Yaman Hussayni Raghid Kadbey Yara Ratel Shereen Yehya Lara Khouzami Hilda E. Ghadieh Hilda E. Ghadieh Amjad Kanaan Sami Azar Frederic Harb Frederic Harb |
| author_facet | Ayman Bou Ghanem Yaman Hussayni Raghid Kadbey Yara Ratel Shereen Yehya Lara Khouzami Hilda E. Ghadieh Hilda E. Ghadieh Amjad Kanaan Sami Azar Frederic Harb Frederic Harb |
| author_sort | Ayman Bou Ghanem |
| collection | DOAJ |
| description | The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation in vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context of aging, OCM dysregulation can contribute to epigenetic modifications and aberrant redox states, accentuating cellular senescence and age-associated pathologies. Furthermore, OCM’s intricate involvement in cancer progression is evident through its capacity to provide essential one-carbon units crucial for nucleotide synthesis and DNA methylation, thereby fueling uncontrolled cell proliferation and tumor development. In neurodegenerative disorders like Alzheimer’s and Parkinson’s, perturbations in OCM pathways are implicated in the dysregulation of neurotransmitter synthesis and mitochondrial dysfunction, contributing to disease pathophysiology. This review underscores the profound impact of OCM in diverse disease contexts, reinforcing the need for a comprehensive understanding of its molecular complexities to pave the way for targeted therapeutic interventions across inflammation, aging and neurodegenerative disorders. |
| first_indexed | 2024-03-08T17:08:14Z |
| format | Article |
| id | doaj.art-24aebb9126874d5d95a7c59ff1615007 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-08T17:08:14Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-24aebb9126874d5d95a7c59ff16150072024-01-04T04:19:05ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-01-011510.3389/fnagi.2023.13224191322419Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseasesAyman Bou Ghanem0Yaman Hussayni1Raghid Kadbey2Yara Ratel3Shereen Yehya4Lara Khouzami5Hilda E. Ghadieh6Hilda E. Ghadieh7Amjad Kanaan8Sami Azar9Frederic Harb10Frederic Harb11Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonCollege of Natural and Health Sciences, Zayed University, Dubai, United Arab EmiratesFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonAUB Diabetes, American University of Beirut Medical Center, Beirut, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, LebanonAUB Diabetes, American University of Beirut Medical Center, Beirut, LebanonThe intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation in vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context of aging, OCM dysregulation can contribute to epigenetic modifications and aberrant redox states, accentuating cellular senescence and age-associated pathologies. Furthermore, OCM’s intricate involvement in cancer progression is evident through its capacity to provide essential one-carbon units crucial for nucleotide synthesis and DNA methylation, thereby fueling uncontrolled cell proliferation and tumor development. In neurodegenerative disorders like Alzheimer’s and Parkinson’s, perturbations in OCM pathways are implicated in the dysregulation of neurotransmitter synthesis and mitochondrial dysfunction, contributing to disease pathophysiology. This review underscores the profound impact of OCM in diverse disease contexts, reinforcing the need for a comprehensive understanding of its molecular complexities to pave the way for targeted therapeutic interventions across inflammation, aging and neurodegenerative disorders.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1322419/fullone carbon metabolismfolateAlzheimer’s diseaseParkinson diseaseagingmitochondrial dysfuntion |
| spellingShingle | Ayman Bou Ghanem Yaman Hussayni Raghid Kadbey Yara Ratel Shereen Yehya Lara Khouzami Hilda E. Ghadieh Hilda E. Ghadieh Amjad Kanaan Sami Azar Frederic Harb Frederic Harb Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases Frontiers in Aging Neuroscience one carbon metabolism folate Alzheimer’s disease Parkinson disease aging mitochondrial dysfuntion |
| title | Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases |
| title_full | Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases |
| title_fullStr | Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases |
| title_full_unstemmed | Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases |
| title_short | Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases |
| title_sort | exploring the complexities of 1c metabolism implications in aging and neurodegenerative diseases |
| topic | one carbon metabolism folate Alzheimer’s disease Parkinson disease aging mitochondrial dysfuntion |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1322419/full |
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