A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression
Purine nucleotides and nucleosides are involved in various human physiological and pathological mechanisms. The pathological deregulation of purinergic signaling contributes to various chronic respiratory diseases. Among the adenosine receptors, A2B has the lowest affinity such that it was long cons...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/5/4428 |
| _version_ | 1797615219304824832 |
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| author | Wiwin Is Effendi Tatsuya Nagano |
| author_facet | Wiwin Is Effendi Tatsuya Nagano |
| author_sort | Wiwin Is Effendi |
| collection | DOAJ |
| description | Purine nucleotides and nucleosides are involved in various human physiological and pathological mechanisms. The pathological deregulation of purinergic signaling contributes to various chronic respiratory diseases. Among the adenosine receptors, A2B has the lowest affinity such that it was long considered to have little pathophysiological significance. Many studies suggest that A2BAR plays protective roles during the early stage of acute inflammation. However, increased adenosine levels during chronic epithelial injury and inflammation might activate A2BAR, resulting in cellular effects relevant to the progression of pulmonary fibrosis. |
| first_indexed | 2024-03-11T07:23:18Z |
| format | Article |
| id | doaj.art-24b06601c3be410aa94cbe064c5d0998 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:23:18Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-24b06601c3be410aa94cbe064c5d09982023-11-17T07:48:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245442810.3390/ijms24054428A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease ProgressionWiwin Is Effendi0Tatsuya Nagano1Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga (UNAIR), Surabaya 60132, IndonesiaDivision of Respiratory Medicine, Department of Internal Medicine, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanPurine nucleotides and nucleosides are involved in various human physiological and pathological mechanisms. The pathological deregulation of purinergic signaling contributes to various chronic respiratory diseases. Among the adenosine receptors, A2B has the lowest affinity such that it was long considered to have little pathophysiological significance. Many studies suggest that A2BAR plays protective roles during the early stage of acute inflammation. However, increased adenosine levels during chronic epithelial injury and inflammation might activate A2BAR, resulting in cellular effects relevant to the progression of pulmonary fibrosis.https://www.mdpi.com/1422-0067/24/5/4428purinergic signalingadenosineA2BARchronic respiratory diseasesidiopathic pulmonary fibrosis |
| spellingShingle | Wiwin Is Effendi Tatsuya Nagano A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression International Journal of Molecular Sciences purinergic signaling adenosine A2BAR chronic respiratory diseases idiopathic pulmonary fibrosis |
| title | A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression |
| title_full | A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression |
| title_fullStr | A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression |
| title_full_unstemmed | A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression |
| title_short | A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression |
| title_sort | a2b adenosine receptor in idiopathic pulmonary fibrosis pursuing proper pit stop to interfere with disease progression |
| topic | purinergic signaling adenosine A2BAR chronic respiratory diseases idiopathic pulmonary fibrosis |
| url | https://www.mdpi.com/1422-0067/24/5/4428 |
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