Study on Suitability of KOD DNA Polymerase for Enzymatic Production of Artificial Nucleic Acids Using Base/Sugar Modified Nucleoside Triphosphates

Study on Suitability of KOD DNA Polymerase for Enzymatic Production of Artificial Nucleic Acids Using Base/Sugar Modified Nucleoside Triphosphates

Recently, KOD and its related DNA polymerases have been used for preparing various modified nucleic acids, including not only base-modified nucleic acids, but also sugar-modified ones, such as bridged/locked nucleic acid (BNA/LNA) which would be promising candidates for nucleic acid drugs. However,...

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Bibliographic Details
Main Authors: Satoshi Obika, Akio Sugiyama, Hiroaki Sawai, Hiroaki Ozaki, Yuuya Kasahara, Hiroki Nara, Yuuki Takano, Masayasu Kuwahara
Format: Article
Language:English
Published: MDPI AG 2010-11-01
Series:Molecules
Subjects:
KOD DNA polymerase
artificial nucleic acids
modified nucleoside triphosphates
Online Access:http://www.mdpi.com/1420-3049/15/11/8229/

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