Microwave-Assisted Atom Transfer Radical Cyclization in the Synthesis of 3,3-Dichloro-γ- and δ-Lactams from <i>N</i>-Alkenyl-Tethered Trichloroacetamides Catalyzed by RuCl<sub>2</sub>(PPh<sub>3</sub>)<sub>3</sub> and Their Cytotoxic Evaluation
An expeditious synthesis of γ- and δ-lactams from tethered alkenyl trichloroacetamides in the presence of 5% of RuCl<sub>2</sub>(PPh<sub>3</sub>)<sub>3</sub> is reported. In this investigation we have demonstrated that microwave activation significantly enhances r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/9/2035 |