Long noncoding RNAs and Alzheimer's disease
Qiong Luo,1,2 Yinghui Chen1,2 1Department of Neurology, Jinshan Hospital, 2Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract: Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. l...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-06-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/long-noncoding-rnas-and-alzheimer39s-disease-peer-reviewed-article-CIA |
| _version_ | 1818692077611909120 |
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| author | Luo Q Chen Y |
| author_facet | Luo Q Chen Y |
| author_sort | Luo Q |
| collection | DOAJ |
| description | Qiong Luo,1,2 Yinghui Chen1,2 1Department of Neurology, Jinshan Hospital, 2Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract: Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer’s disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer’s disease and focus on some specific lncRNAs that may underlie Alzheimer’s disease pathophysiology and therefore could be potential therapeutic targets. Keywords: lncRNA, Alzheimer’s disease, ncRNAs, amyloid β peptide, BACE1, BC200, BACE1-AS |
| first_indexed | 2024-12-17T12:52:03Z |
| format | Article |
| id | doaj.art-24b954630eee41cc98bf88287c58e828 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-17T12:52:03Z |
| publishDate | 2016-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-24b954630eee41cc98bf88287c58e8282022-12-21T21:47:35ZengDove Medical PressClinical Interventions in Aging1178-19982016-06-01Volume 1186787227664Long noncoding RNAs and Alzheimer's diseaseLuo QChen YQiong Luo,1,2 Yinghui Chen1,2 1Department of Neurology, Jinshan Hospital, 2Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China Abstract: Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer’s disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer’s disease and focus on some specific lncRNAs that may underlie Alzheimer’s disease pathophysiology and therefore could be potential therapeutic targets. Keywords: lncRNA, Alzheimer’s disease, ncRNAs, amyloid β peptide, BACE1, BC200, BACE1-AShttps://www.dovepress.com/long-noncoding-rnas-and-alzheimer39s-disease-peer-reviewed-article-CIAlncRNAAlzheimer’s diseasencRNAsAmyloid β peptide，β-site amyloid precursor protein cleaving enzyme-1 |
| spellingShingle | Luo Q Chen Y Long noncoding RNAs and Alzheimer's disease Clinical Interventions in Aging lncRNA Alzheimer’s disease ncRNAs Amyloid β peptide，β-site amyloid precursor protein cleaving enzyme-1 |
| title | Long noncoding RNAs and Alzheimer's disease |
| title_full | Long noncoding RNAs and Alzheimer's disease |
| title_fullStr | Long noncoding RNAs and Alzheimer's disease |
| title_full_unstemmed | Long noncoding RNAs and Alzheimer's disease |
| title_short | Long noncoding RNAs and Alzheimer's disease |
| title_sort | long noncoding rnas and alzheimer 39 s disease |
| topic | lncRNA Alzheimer’s disease ncRNAs Amyloid β peptide，β-site amyloid precursor protein cleaving enzyme-1 |
| url | https://www.dovepress.com/long-noncoding-rnas-and-alzheimer39s-disease-peer-reviewed-article-CIA |
| work_keys_str_mv | AT luoq longnoncodingrnasandalzheimer39sdisease AT cheny longnoncodingrnasandalzheimer39sdisease |