Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adults
BackgroundWith growing concerns about global population aging, comorbidity, and disability have emerged as key variables that influence the health of the older adults in terms of disease and function. This study sought to examine the impact of comorbidity and impairment using disease and functional...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1162425/full |
| _version_ | 1797791569622859776 |
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| author | Ying Wang Tianyu Meng Wei Yang Miaojia Yan Xianming Su Xiaohong Wang Lihong Chen Yanping Ren |
| author_facet | Ying Wang Tianyu Meng Wei Yang Miaojia Yan Xianming Su Xiaohong Wang Lihong Chen Yanping Ren |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | BackgroundWith growing concerns about global population aging, comorbidity, and disability have emerged as key variables that influence the health of the older adults in terms of disease and function. This study sought to examine the impact of comorbidity and impairment using disease and functional status indicators of all-cause mortality in the older adults. Hypertension, which was chosen as the indicator chosen for disease, has the greatest prevalence in the older population. A total of 15 self-reported chronic conditions were added as indicators of comorbidity, and grip strength was chosen as a measure of functional status. The study also evaluated the association between grip strength and comorbidity, as well as its consequences on all-cause death and survival in a hypertensive senior population.MethodsWe chose a total of 2,990 hypertensive participants aged ≥60 years whose data for grip strength were collected in the National Health and Nutrition Examination Survey conducted between 2011 and 2014. The association of all-cause death with grip strength and comorbidity was examined using a Cox proportional hazard regression model. The interaction between comorbidity and all-cause mortality, as well as its association with grip strength, was also examined.ResultsThe hazard ratio [95% confidence intervals (CIs)] for all-cause mortality in the highest grip strength tertile was 0.266 (0.168–0.419), compared to the lowest grip strength tertile. The all-cause mortality decreased with an increase in the number of co-morbidities [2.677 (1.557–4.603) in the group with ≥3 chronic diseases]. The weighted generalized model revealed a negative correlation between grip strength and comorbidities in more than three groups after accounting for all possible variables (β = −2.219, −3.178 ~ −1.260, p < 0.001). The risk of mortality reduced with increasing grip strength in patients with ≥3 comorbidities (p-value for trend <0.05), but no meaningful difference was found in the interaction between comorbidities and grip strength (p-value for interaction >0.05).ConclusionIn older hypertension patients, grip strength and comorbidities were correlated with all-cause death, and there was a negative correlation between grip strength and comorbidities. Higher grip strength was associated with fewer fatalities in patients with ≥3 comorbidities, suggesting that functional exercise can improve the prognosis of comorbidities. |
| first_indexed | 2024-03-13T02:20:44Z |
| format | Article |
| id | doaj.art-24b96e95343d4d5f9395f1f032dbc792 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-13T02:20:44Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Public Health |
| spelling | doaj.art-24b96e95343d4d5f9395f1f032dbc7922023-06-30T09:43:51ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-06-011110.3389/fpubh.2023.11624251162425Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adultsYing Wang0Tianyu Meng1Wei Yang2Miaojia Yan3Xianming Su4Xiaohong Wang5Lihong Chen6Yanping Ren7International Medical Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Medical Administration, The First Affiliated Hospital of Xi 'an Jiaotong University, Xi 'an, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, ChinaInternational Medical Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, ChinaBackgroundWith growing concerns about global population aging, comorbidity, and disability have emerged as key variables that influence the health of the older adults in terms of disease and function. This study sought to examine the impact of comorbidity and impairment using disease and functional status indicators of all-cause mortality in the older adults. Hypertension, which was chosen as the indicator chosen for disease, has the greatest prevalence in the older population. A total of 15 self-reported chronic conditions were added as indicators of comorbidity, and grip strength was chosen as a measure of functional status. The study also evaluated the association between grip strength and comorbidity, as well as its consequences on all-cause death and survival in a hypertensive senior population.MethodsWe chose a total of 2,990 hypertensive participants aged ≥60 years whose data for grip strength were collected in the National Health and Nutrition Examination Survey conducted between 2011 and 2014. The association of all-cause death with grip strength and comorbidity was examined using a Cox proportional hazard regression model. The interaction between comorbidity and all-cause mortality, as well as its association with grip strength, was also examined.ResultsThe hazard ratio [95% confidence intervals (CIs)] for all-cause mortality in the highest grip strength tertile was 0.266 (0.168–0.419), compared to the lowest grip strength tertile. The all-cause mortality decreased with an increase in the number of co-morbidities [2.677 (1.557–4.603) in the group with ≥3 chronic diseases]. The weighted generalized model revealed a negative correlation between grip strength and comorbidities in more than three groups after accounting for all possible variables (β = −2.219, −3.178 ~ −1.260, p < 0.001). The risk of mortality reduced with increasing grip strength in patients with ≥3 comorbidities (p-value for trend <0.05), but no meaningful difference was found in the interaction between comorbidities and grip strength (p-value for interaction >0.05).ConclusionIn older hypertension patients, grip strength and comorbidities were correlated with all-cause death, and there was a negative correlation between grip strength and comorbidities. Higher grip strength was associated with fewer fatalities in patients with ≥3 comorbidities, suggesting that functional exercise can improve the prognosis of comorbidities.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1162425/fullhandgrip strengthcomorbidityhypertensionolder adultsmortality |
| spellingShingle | Ying Wang Tianyu Meng Wei Yang Miaojia Yan Xianming Su Xiaohong Wang Lihong Chen Yanping Ren Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adults Frontiers in Public Health handgrip strength comorbidity hypertension older adults mortality |
| title | Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adults |
| title_full | Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adults |
| title_fullStr | Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adults |
| title_full_unstemmed | Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adults |
| title_short | Association of grip strength and comorbidities with all-cause mortality in the older hypertensive adults |
| title_sort | association of grip strength and comorbidities with all cause mortality in the older hypertensive adults |
| topic | handgrip strength comorbidity hypertension older adults mortality |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1162425/full |
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