Total Synthesis of the Proposed Structure of Indolyl 1,2-Propanediol Alkaloid, 1-(1<i>H</i>-Indol-3-yloxy)propan-2-ol
The first total synthesis of the proposed structure of unprecedented indolyl derivative bearing 1,2-propanediol moiety is described. Isomerization of 3-alkoxyindolines through indolenium intermediates was the key step in the total synthesis. <sup>1</sup>H, <sup>13</sup>C-NMR,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
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| Series: | Chemistry |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-8549/5/4/177 |
| Summary: | The first total synthesis of the proposed structure of unprecedented indolyl derivative bearing 1,2-propanediol moiety is described. Isomerization of 3-alkoxyindolines through indolenium intermediates was the key step in the total synthesis. <sup>1</sup>H, <sup>13</sup>C-NMR, IR, and HRMS spectra of the synthetic compound drastically differed to those of the originally reported structure, which suggests the natural product requires revision. |
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| ISSN: | 2624-8549 |