Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis
BackgroundSupplemental oxygen leads to an increase in peripheral vascular resistance which finally increases systemic blood pressure in healthy subjects and patients with coronary artery disease, heart failure, undergoing heart surgery, and with sepsis. However, it is unknown whether this effect can...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1200223/full |
| _version_ | 1827937006337916928 |
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| author | Christian Reiterer Christian Reiterer Edith Fleischmann Edith Fleischmann Barbara Kabon Barbara Kabon Alexander Taschner Alexander Taschner Andrea Kurz Andrea Kurz Andrea Kurz Nikolas Adamowitsch Markus Falkner von Sonnenburg Melanie Fraunschiel Alexandra Graf |
| author_facet | Christian Reiterer Christian Reiterer Edith Fleischmann Edith Fleischmann Barbara Kabon Barbara Kabon Alexander Taschner Alexander Taschner Andrea Kurz Andrea Kurz Andrea Kurz Nikolas Adamowitsch Markus Falkner von Sonnenburg Melanie Fraunschiel Alexandra Graf |
| author_sort | Christian Reiterer |
| collection | DOAJ |
| description | BackgroundSupplemental oxygen leads to an increase in peripheral vascular resistance which finally increases systemic blood pressure in healthy subjects and patients with coronary artery disease, heart failure, undergoing heart surgery, and with sepsis. However, it is unknown whether this effect can also be observed in anesthetized patients having surgery. Thus, we evaluated in this exploratory analysis of a randomized controlled trial the effect of 80% versus 30% oxygen on intraoperative blood pressure and heart rate.MethodsWe present data from a previous study including 258 patients, who were randomized to a perioperative inspiratory FiO2 of 0.8 (128 patients) versus 0.3 (130 patients) for major abdominal surgery. Continuous arterial blood pressure values were recorded every three seconds and were exported from the electronic anesthesia record system. We calculated time-weighted average (TWA) and Average Real Variability (ARV) of mean arterial blood pressure and of heart rate.ResultsThere was no significant difference in TWA of mean arterial pressure between the 80% (80 mmHg [76, 85]) and 30% (81 mmHg [77, 86]) oxygen group (effect estimate −0.16 mmHg, CI –1.83 to 1.51; p = 0.85). There was also no significant difference in TWA of heart rate between the 80 and 30% oxygen group (median TWA of heart rate in the 80% oxygen group: 65 beats.min−1 [58, 72], and in the 30% oxygen group: 64 beats.min−1 [58; 70]; effect estimate: 0.12 beats.min−1, CI –2.55 to 2.8, p = 0.94). Also for ARV values, no significant differences between groups could be detected.ConclusionIn contrast to previous results, we did not observe a significant increase in blood pressure or a significant decrease in heart rate in patients, who received 80% oxygen as compared to patients, who received 30% oxygen during surgery and for the first two postoperative hours. Thus, hemodynamic effects of supplemental oxygen might play a negligible role in anesthetized patients.Clinical Trail Registrationhttps://clinicaltrials.gov/ct2/show/NCT03366857?term=vienna&cond=oxygen&draw=2&rank=1 |
| first_indexed | 2024-03-13T08:19:24Z |
| format | Article |
| id | doaj.art-24bd716f1b1d4bab9ca61c5d9fec0aa8 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T08:19:24Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-24bd716f1b1d4bab9ca61c5d9fec0aa82023-05-31T10:40:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-05-011010.3389/fmed.2023.12002231200223Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysisChristian Reiterer0Christian Reiterer1Edith Fleischmann2Edith Fleischmann3Barbara Kabon4Barbara Kabon5Alexander Taschner6Alexander Taschner7Andrea Kurz8Andrea Kurz9Andrea Kurz10Nikolas Adamowitsch11Markus Falkner von Sonnenburg12Melanie Fraunschiel13Alexandra Graf14Department of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, AustriaOutcome Research Consortium, Cleveland, OH, United StatesDepartment of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, AustriaOutcome Research Consortium, Cleveland, OH, United StatesDepartment of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, AustriaOutcome Research Consortium, Cleveland, OH, United StatesDepartment of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, AustriaOutcome Research Consortium, Cleveland, OH, United StatesOutcome Research Consortium, Cleveland, OH, United StatesDepartment of General Anesthesiology, Cleveland Clinic, Anesthesia Institute, Cleveland, OH, United StatesDepartment of General Anesthesiology, Emergency Medicine and Intensive Care Medicine, Medical University of Graz, Graz, AustriaDepartment of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, AustriaIT Systems and Communications, Medical University of Vienna, Vienna, AustriaCenter for Medical Data Science, Medical University of Vienna, Vienna, AustriaBackgroundSupplemental oxygen leads to an increase in peripheral vascular resistance which finally increases systemic blood pressure in healthy subjects and patients with coronary artery disease, heart failure, undergoing heart surgery, and with sepsis. However, it is unknown whether this effect can also be observed in anesthetized patients having surgery. Thus, we evaluated in this exploratory analysis of a randomized controlled trial the effect of 80% versus 30% oxygen on intraoperative blood pressure and heart rate.MethodsWe present data from a previous study including 258 patients, who were randomized to a perioperative inspiratory FiO2 of 0.8 (128 patients) versus 0.3 (130 patients) for major abdominal surgery. Continuous arterial blood pressure values were recorded every three seconds and were exported from the electronic anesthesia record system. We calculated time-weighted average (TWA) and Average Real Variability (ARV) of mean arterial blood pressure and of heart rate.ResultsThere was no significant difference in TWA of mean arterial pressure between the 80% (80 mmHg [76, 85]) and 30% (81 mmHg [77, 86]) oxygen group (effect estimate −0.16 mmHg, CI –1.83 to 1.51; p = 0.85). There was also no significant difference in TWA of heart rate between the 80 and 30% oxygen group (median TWA of heart rate in the 80% oxygen group: 65 beats.min−1 [58, 72], and in the 30% oxygen group: 64 beats.min−1 [58; 70]; effect estimate: 0.12 beats.min−1, CI –2.55 to 2.8, p = 0.94). Also for ARV values, no significant differences between groups could be detected.ConclusionIn contrast to previous results, we did not observe a significant increase in blood pressure or a significant decrease in heart rate in patients, who received 80% oxygen as compared to patients, who received 30% oxygen during surgery and for the first two postoperative hours. Thus, hemodynamic effects of supplemental oxygen might play a negligible role in anesthetized patients.Clinical Trail Registrationhttps://clinicaltrials.gov/ct2/show/NCT03366857?term=vienna&cond=oxygen&draw=2&rank=1https://www.frontiersin.org/articles/10.3389/fmed.2023.1200223/fullsupplemental oxygenhemodynamicsblood pressureheart ratemajor abdominal surgeries |
| spellingShingle | Christian Reiterer Christian Reiterer Edith Fleischmann Edith Fleischmann Barbara Kabon Barbara Kabon Alexander Taschner Alexander Taschner Andrea Kurz Andrea Kurz Andrea Kurz Nikolas Adamowitsch Markus Falkner von Sonnenburg Melanie Fraunschiel Alexandra Graf Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis Frontiers in Medicine supplemental oxygen hemodynamics blood pressure heart rate major abdominal surgeries |
| title | Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis |
| title_full | Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis |
| title_fullStr | Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis |
| title_full_unstemmed | Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis |
| title_short | Hemodynamic effects of intraoperative 30% versus 80% oxygen concentrations: an exploratory analysis |
| title_sort | hemodynamic effects of intraoperative 30 versus 80 oxygen concentrations an exploratory analysis |
| topic | supplemental oxygen hemodynamics blood pressure heart rate major abdominal surgeries |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1200223/full |
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