A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs

A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs

Cefquinome is widely used to treat respiratory tract diseases of swine. While extra-label dosages of cefquinome could improve clinical efficacy, they might lead to excessively high residues in animal-derived food. In this study, a physiologically based pharmacokinetic (PBPK) model was calibrated bas...

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Bibliographic Details
Main Authors: Kun Mi, Lei Sun, Yixuan Hou, Xin Cai, Kaixiang Zhou, Wenjin Ma, Xiangyue Xu, Yuanhu Pan, Zhenli Liu, Lingli Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-08-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431683/?tool=EBI

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