Epidemiology of Non-Hodgkin’s Lymphoma
Non-Hodgins’s lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL accounts for 4% of US cancer diagnoses, and incidence...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Medical Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3271/9/1/5 |
| _version_ | 1827596804286316544 |
|---|---|
| author | Krishna C. Thandra Adam Barsouk Kalyan Saginala Sandeep Anand Padala Alexander Barsouk Prashanth Rawla |
| author_facet | Krishna C. Thandra Adam Barsouk Kalyan Saginala Sandeep Anand Padala Alexander Barsouk Prashanth Rawla |
| author_sort | Krishna C. Thandra |
| collection | DOAJ |
| description | Non-Hodgins’s lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL accounts for 4% of US cancer diagnoses, and incidence has increased 168% since 1975 (while survival has improved 158%). NHL is more common among men, those >65 years old, and those with autoimmune disease or a family history of hematological malignancies. NHL is a heterogenous disease, with each subtype associated with different risk factors. Marginal zone lymphoma (MZL) is strongly associated with Sjogren’s syndrome (SS) and Hashimoto’s thyroiditis, while peripheral T-cell lymphoma (PTCL) is most associated with celiac disease. Occupational exposures among farm workers or painters increases the risk of most of the common subtypes. Prior radiation treatment, obesity, and smoking are most highly associated with diffuse large B-cell lymphoma (DLBCL), while breast implants have been rarely associated with anaplastic large cell lymphoma (ALCL). Infection with Epstein–Barr Virus (EBV) is strongly associated with endemic Burkitts lymphoma. HIV and human herpes virus 8 (HHV-8), is predisposed to several subtypes of DLBCL, and human T-cell lymphoma virus (HTLV-1) is a causative agent of T-cell lymphomas. Obesity and vitamin D deficiency worsen NHL survival. Atopic diseases and alcohol consumption seem to be protective against NHL. |
| first_indexed | 2024-03-09T03:15:40Z |
| format | Article |
| id | doaj.art-24c0708bf41b41acbe8ce8b734e46b0d |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-03-09T03:15:40Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-24c0708bf41b41acbe8ce8b734e46b0d2023-12-03T15:20:07ZengMDPI AGMedical Sciences2076-32712021-01-0191510.3390/medsci9010005Epidemiology of Non-Hodgkin’s LymphomaKrishna C. Thandra0Adam Barsouk1Kalyan Saginala2Sandeep Anand Padala3Alexander Barsouk4Prashanth Rawla5Department of Pulmonary and Critical Care Medicine, Sentara Virginia Beach General Hospital, Virginia Beach, VA 23455, USASidney Kimmel Cancer Center, Jefferson University, Philadelphia, PA 19107, USAPlains Regional Medical Group Internal Medicine, Clovis, NM 88101, USADepartment of Medicine, Nephrology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USAHematologist-Oncologist, Allegheny Health Network, Pittsburgh, PA 15212, USADepartment of Medicine, Sovah Health, Martinsville, VA 24112, USANon-Hodgins’s lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL accounts for 4% of US cancer diagnoses, and incidence has increased 168% since 1975 (while survival has improved 158%). NHL is more common among men, those >65 years old, and those with autoimmune disease or a family history of hematological malignancies. NHL is a heterogenous disease, with each subtype associated with different risk factors. Marginal zone lymphoma (MZL) is strongly associated with Sjogren’s syndrome (SS) and Hashimoto’s thyroiditis, while peripheral T-cell lymphoma (PTCL) is most associated with celiac disease. Occupational exposures among farm workers or painters increases the risk of most of the common subtypes. Prior radiation treatment, obesity, and smoking are most highly associated with diffuse large B-cell lymphoma (DLBCL), while breast implants have been rarely associated with anaplastic large cell lymphoma (ALCL). Infection with Epstein–Barr Virus (EBV) is strongly associated with endemic Burkitts lymphoma. HIV and human herpes virus 8 (HHV-8), is predisposed to several subtypes of DLBCL, and human T-cell lymphoma virus (HTLV-1) is a causative agent of T-cell lymphomas. Obesity and vitamin D deficiency worsen NHL survival. Atopic diseases and alcohol consumption seem to be protective against NHL.https://www.mdpi.com/2076-3271/9/1/5NHLnon-Hodgkin’s lymphomaepidemiologyincidenceprevalencemortality |
| spellingShingle | Krishna C. Thandra Adam Barsouk Kalyan Saginala Sandeep Anand Padala Alexander Barsouk Prashanth Rawla Epidemiology of Non-Hodgkin’s Lymphoma Medical Sciences NHL non-Hodgkin’s lymphoma epidemiology incidence prevalence mortality |
| title | Epidemiology of Non-Hodgkin’s Lymphoma |
| title_full | Epidemiology of Non-Hodgkin’s Lymphoma |
| title_fullStr | Epidemiology of Non-Hodgkin’s Lymphoma |
| title_full_unstemmed | Epidemiology of Non-Hodgkin’s Lymphoma |
| title_short | Epidemiology of Non-Hodgkin’s Lymphoma |
| title_sort | epidemiology of non hodgkin s lymphoma |
| topic | NHL non-Hodgkin’s lymphoma epidemiology incidence prevalence mortality |
| url | https://www.mdpi.com/2076-3271/9/1/5 |
| work_keys_str_mv | AT krishnacthandra epidemiologyofnonhodgkinslymphoma AT adambarsouk epidemiologyofnonhodgkinslymphoma AT kalyansaginala epidemiologyofnonhodgkinslymphoma AT sandeepanandpadala epidemiologyofnonhodgkinslymphoma AT alexanderbarsouk epidemiologyofnonhodgkinslymphoma AT prashanthrawla epidemiologyofnonhodgkinslymphoma |