The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis
Abstract Background Perioperative prophylactic dexamethasone is commonly administered to reduce postoperative nausea and vomiting (PONV) and pain after surgery. In this study, we aimed to systematically review the efficacy and adverse effects of perioperative dexamethasone administration. Methods We...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-10-01
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| Series: | Ain Shams Journal of Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s42077-023-00376-w |
| _version_ | 1797663587494264832 |
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| author | Mohammad Javad Najafzadeh Mohadeseh Shafiei Meraj Sharifi Parvaneh Nazari Naser Nasiri Morteza Hashemian |
| author_facet | Mohammad Javad Najafzadeh Mohadeseh Shafiei Meraj Sharifi Parvaneh Nazari Naser Nasiri Morteza Hashemian |
| author_sort | Mohammad Javad Najafzadeh |
| collection | DOAJ |
| description | Abstract Background Perioperative prophylactic dexamethasone is commonly administered to reduce postoperative nausea and vomiting (PONV) and pain after surgery. In this study, we aimed to systematically review the efficacy and adverse effects of perioperative dexamethasone administration. Methods We conducted a systematic search until January 2023 in scientific databases, including PubMed, Scopus, Embase, Web of Science, and Google Scholar. After assessing the methodological quality of relevant studies, we synthesized those focusing on PONV, oral food intake tolerance, impaired wound healing, major postoperative complications, and postoperative infections following the perioperative administration of dexamethasone. Results A total of 27 studies were included in this systematic review and meta-analysis. The dexamethasone group showed decreased PONV (OR = 0.19; 95% CI 0.06–0.55), increased oral food intake tolerance (OR = 7.38; 95% CI 1.07–51.11), increased risk of impaired wound healing (OR = .48; 95% CI 0.52–4.21), decreased probability of postoperative infection (OR = 0.61; 95% CI 0.51–0.72), and increased risk of major postoperative complications (OR = 1.27; 95% CI 0.68–2.39) compared to the controls. Conclusions The results of our pooled data analysis showed that dexamethasone was superior to the control in terms of PONV, oral food intake tolerance, and postoperative infections. |
| first_indexed | 2024-03-11T19:16:48Z |
| format | Article |
| id | doaj.art-24c125fdefbf4d63b876f49d47d2b1a6 |
| institution | Directory Open Access Journal |
| issn | 2090-925X |
| language | English |
| last_indexed | 2024-03-11T19:16:48Z |
| publishDate | 2023-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Ain Shams Journal of Anesthesiology |
| spelling | doaj.art-24c125fdefbf4d63b876f49d47d2b1a62023-10-08T11:07:24ZengSpringerOpenAin Shams Journal of Anesthesiology2090-925X2023-10-0115111210.1186/s42077-023-00376-wThe efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysisMohammad Javad Najafzadeh0Mohadeseh Shafiei1Meraj Sharifi2Parvaneh Nazari3Naser Nasiri4Morteza Hashemian5Faculty of Medicine, Kerman University of Medical SciencesFaculty of Medicine, Kerman University of Medical SciencesFaculty of Medicine, Kerman University of Medical SciencesClinical Research Development Unit, Shafa Hospital, Kerman University of Medical SciencesHIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical SciencesDepartment of Anesthesiology and Pain Medicine, Kerman University of Medical SciencesAbstract Background Perioperative prophylactic dexamethasone is commonly administered to reduce postoperative nausea and vomiting (PONV) and pain after surgery. In this study, we aimed to systematically review the efficacy and adverse effects of perioperative dexamethasone administration. Methods We conducted a systematic search until January 2023 in scientific databases, including PubMed, Scopus, Embase, Web of Science, and Google Scholar. After assessing the methodological quality of relevant studies, we synthesized those focusing on PONV, oral food intake tolerance, impaired wound healing, major postoperative complications, and postoperative infections following the perioperative administration of dexamethasone. Results A total of 27 studies were included in this systematic review and meta-analysis. The dexamethasone group showed decreased PONV (OR = 0.19; 95% CI 0.06–0.55), increased oral food intake tolerance (OR = 7.38; 95% CI 1.07–51.11), increased risk of impaired wound healing (OR = .48; 95% CI 0.52–4.21), decreased probability of postoperative infection (OR = 0.61; 95% CI 0.51–0.72), and increased risk of major postoperative complications (OR = 1.27; 95% CI 0.68–2.39) compared to the controls. Conclusions The results of our pooled data analysis showed that dexamethasone was superior to the control in terms of PONV, oral food intake tolerance, and postoperative infections.https://doi.org/10.1186/s42077-023-00376-wDexamethasoneIntraoperativePerioperativeNauseaVomiting |
| spellingShingle | Mohammad Javad Najafzadeh Mohadeseh Shafiei Meraj Sharifi Parvaneh Nazari Naser Nasiri Morteza Hashemian The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis Ain Shams Journal of Anesthesiology Dexamethasone Intraoperative Perioperative Nausea Vomiting |
| title | The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis |
| title_full | The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis |
| title_fullStr | The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis |
| title_full_unstemmed | The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis |
| title_short | The efficacy and safety of perioperative administration of dexamethasone: a systematic review and meta-analysis |
| title_sort | efficacy and safety of perioperative administration of dexamethasone a systematic review and meta analysis |
| topic | Dexamethasone Intraoperative Perioperative Nausea Vomiting |
| url | https://doi.org/10.1186/s42077-023-00376-w |
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