The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles
Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah H Al-Mohy, Magdi Mohamed Ghannam Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Mohamed Anwar K AbdelhalimBiomedical Physics, Department of Physics and Astronomy, College of Science...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-01-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/the-protective-roles-of-vitamin-e-and-alpha-lipoic-acid-against-nephro-peer-reviewed-article-IJN |
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| author | Abdelhalim MAK Qaid HAY Al-Mohy YH Ghannam MM |
| author_facet | Abdelhalim MAK Qaid HAY Al-Mohy YH Ghannam MM |
| author_sort | Abdelhalim MAK |
| collection | DOAJ |
| description | Mohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah H Al-Mohy, Magdi Mohamed Ghannam Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Mohamed Anwar K AbdelhalimBiomedical Physics, Department of Physics and Astronomy, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi ArabiaTel +966509649633Email abdelhalimmak@yahoo.comBackground: Recently, use of nanotechnology in biomedical applications such as drug delivery and diagnostic and therapeutic tools has increased greatly. This study evaluated gold nanoparticle (GNPs)-induced nephrotoxic effects in rats in vivo, and examined protective effects of alpha-lipoic acid (α-Lip) and Vitamin E (Vit E) against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs.Materials and Methods: Twenty-four male Wistar-Kyoto rats (220– 240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/kg/day Vit E or 200 mg/kg/day α-Lip. Serum was prepared for biochemical analyses. Kidney function was evaluated through measurement of creatinine (CR), uric acid (URIC), and blood urea nitrogen (BUN). Oxidative stress and lipid peroxidation were evaluated by measurement of reduced glutathione (GSH) and malondialdehyde (MDA) in kidney tissue homogenates.Results and Conclusions: The results showed a significant rise in serum kidney function biomarkers including urea, URIC, CR, and BUN in GNP-treated rats compared to normal control rats. Furthermore, GNPs led to decreased GSH and elevated MDA levels. Vit E or α-Lip supplementation showed a beneficial effect against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs. This study suggests that use of natural antioxidants in combination with GNPs may be a useful tool in preventing GNPs toxicity.Keywords: gold nanoparticles, Vitamin E, alpha-lipoic acid, nephrotoxicity, lipid peroxidation, natural antioxidants |
| first_indexed | 2024-12-17T13:58:24Z |
| format | Article |
| id | doaj.art-24c13c72629e4d7881de56bd0959f0a5 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-17T13:58:24Z |
| publishDate | 2020-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-24c13c72629e4d7881de56bd0959f0a52022-12-21T21:45:51ZengDove Medical PressInternational Journal of Nanomedicine1178-20132020-01-01Volume 1572973451496The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold NanoparticlesAbdelhalim MAKQaid HAYAl-Mohy YHGhannam MMMohamed Anwar K Abdelhalim, Huda AY Qaid, Yanallah H Al-Mohy, Magdi Mohamed Ghannam Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Mohamed Anwar K AbdelhalimBiomedical Physics, Department of Physics and Astronomy, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi ArabiaTel +966509649633Email abdelhalimmak@yahoo.comBackground: Recently, use of nanotechnology in biomedical applications such as drug delivery and diagnostic and therapeutic tools has increased greatly. This study evaluated gold nanoparticle (GNPs)-induced nephrotoxic effects in rats in vivo, and examined protective effects of alpha-lipoic acid (α-Lip) and Vitamin E (Vit E) against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs.Materials and Methods: Twenty-four male Wistar-Kyoto rats (220– 240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/kg/day Vit E or 200 mg/kg/day α-Lip. Serum was prepared for biochemical analyses. Kidney function was evaluated through measurement of creatinine (CR), uric acid (URIC), and blood urea nitrogen (BUN). Oxidative stress and lipid peroxidation were evaluated by measurement of reduced glutathione (GSH) and malondialdehyde (MDA) in kidney tissue homogenates.Results and Conclusions: The results showed a significant rise in serum kidney function biomarkers including urea, URIC, CR, and BUN in GNP-treated rats compared to normal control rats. Furthermore, GNPs led to decreased GSH and elevated MDA levels. Vit E or α-Lip supplementation showed a beneficial effect against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs. This study suggests that use of natural antioxidants in combination with GNPs may be a useful tool in preventing GNPs toxicity.Keywords: gold nanoparticles, Vitamin E, alpha-lipoic acid, nephrotoxicity, lipid peroxidation, natural antioxidantshttps://www.dovepress.com/the-protective-roles-of-vitamin-e-and-alpha-lipoic-acid-against-nephro-peer-reviewed-article-IJNgold nanoparticlesvitamin ealpha-lipoic acidnephrotoxicitylipid peroxidationnatural antioxidants |
| spellingShingle | Abdelhalim MAK Qaid HAY Al-Mohy YH Ghannam MM The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles International Journal of Nanomedicine gold nanoparticles vitamin e alpha-lipoic acid nephrotoxicity lipid peroxidation natural antioxidants |
| title | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles |
| title_full | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles |
| title_fullStr | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles |
| title_full_unstemmed | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles |
| title_short | The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles |
| title_sort | protective roles of vitamin e and alpha lipoic acid against nephrotoxicity lipid peroxidation and inflammatory damage induced by gold nanoparticles |
| topic | gold nanoparticles vitamin e alpha-lipoic acid nephrotoxicity lipid peroxidation natural antioxidants |
| url | https://www.dovepress.com/the-protective-roles-of-vitamin-e-and-alpha-lipoic-acid-against-nephro-peer-reviewed-article-IJN |
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