Human Papillomavirus Vaccines: An Updated Review

Human papillomavirus (HPV) vaccines, which were introduced in many countries in the past decade, have shown promising results in decreasing HPV infection and related diseases, such as warts and precancerous lesions. In this review, we present the updated information about current HPV vaccines, focus...

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Main Authors: Liqin Cheng, Yan Wang, Juan Du
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/8/3/391
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author Liqin Cheng
Yan Wang
Juan Du
author_facet Liqin Cheng
Yan Wang
Juan Du
author_sort Liqin Cheng
collection DOAJ
description Human papillomavirus (HPV) vaccines, which were introduced in many countries in the past decade, have shown promising results in decreasing HPV infection and related diseases, such as warts and precancerous lesions. In this review, we present the updated information about current HPV vaccines, focusing on vaccine coverage and efficacy. In addition, pan-gender vaccination and current clinical trials are also discussed. Currently, more efforts should be put into increasing the vaccine’s coverage, especially in low- and middle-income countries. Provision of education on HPV and vaccination is one of the most important methods to achieve this. Vaccines that target HPV types not included in current vaccines are the next stage in vaccine development. In the future, all HPV-related cancers, such as head and neck cancer, and anal cancer, should be tracked and evaluated, especially in countries that have introduced pan-gender vaccination programs. Therapeutic vaccines, in combination with other cancer treatments, should continue to be investigated.
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spelling doaj.art-24c7a73a5051409992f520c437963a992023-11-20T06:59:35ZengMDPI AGVaccines2076-393X2020-07-018339110.3390/vaccines8030391Human Papillomavirus Vaccines: An Updated ReviewLiqin Cheng0Yan Wang1Juan Du2Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 17177 Stockholm, SwedenDepartment of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 17177 Stockholm, SwedenDepartment of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 17177 Stockholm, SwedenHuman papillomavirus (HPV) vaccines, which were introduced in many countries in the past decade, have shown promising results in decreasing HPV infection and related diseases, such as warts and precancerous lesions. In this review, we present the updated information about current HPV vaccines, focusing on vaccine coverage and efficacy. In addition, pan-gender vaccination and current clinical trials are also discussed. Currently, more efforts should be put into increasing the vaccine’s coverage, especially in low- and middle-income countries. Provision of education on HPV and vaccination is one of the most important methods to achieve this. Vaccines that target HPV types not included in current vaccines are the next stage in vaccine development. In the future, all HPV-related cancers, such as head and neck cancer, and anal cancer, should be tracked and evaluated, especially in countries that have introduced pan-gender vaccination programs. Therapeutic vaccines, in combination with other cancer treatments, should continue to be investigated.https://www.mdpi.com/2076-393X/8/3/391human papillomavirusvaccineCervarixGardasilGardasil 9
spellingShingle Liqin Cheng
Yan Wang
Juan Du
Human Papillomavirus Vaccines: An Updated Review
Vaccines
human papillomavirus
vaccine
Cervarix
Gardasil
Gardasil 9
title Human Papillomavirus Vaccines: An Updated Review
title_full Human Papillomavirus Vaccines: An Updated Review
title_fullStr Human Papillomavirus Vaccines: An Updated Review
title_full_unstemmed Human Papillomavirus Vaccines: An Updated Review
title_short Human Papillomavirus Vaccines: An Updated Review
title_sort human papillomavirus vaccines an updated review
topic human papillomavirus
vaccine
Cervarix
Gardasil
Gardasil 9
url https://www.mdpi.com/2076-393X/8/3/391
work_keys_str_mv AT liqincheng humanpapillomavirusvaccinesanupdatedreview
AT yanwang humanpapillomavirusvaccinesanupdatedreview
AT juandu humanpapillomavirusvaccinesanupdatedreview