A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor
We present histological, immunohistochemical and molecular features of oncocytic papillary cystadenocarcinoma, a rare neoplasm of the salivary and parotid glands, in an 82-year-old Japanese man. The resected tumor was solid nodular mass with fibrous capsule. The tumor was composed of papillary proli...
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Elsevier
2016-09-01
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| Series: | Human Pathology: Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214330015300456 |
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| author | Shoko Kure, MD, PhD Ryuichi Wada, MD, PhD Wei-Xia Peng, MD, PhD Hideaki Ishii, MD, PhD Taeko Kitamura, MT Takenori Fujii, MT Shunta Inai, MD, PhD Toshitaka Nagao, MD, PhD Zenya Naito, MD, PhD |
| author_facet | Shoko Kure, MD, PhD Ryuichi Wada, MD, PhD Wei-Xia Peng, MD, PhD Hideaki Ishii, MD, PhD Taeko Kitamura, MT Takenori Fujii, MT Shunta Inai, MD, PhD Toshitaka Nagao, MD, PhD Zenya Naito, MD, PhD |
| author_sort | Shoko Kure, MD, PhD |
| collection | DOAJ |
| description | We present histological, immunohistochemical and molecular features of oncocytic papillary cystadenocarcinoma, a rare neoplasm of the salivary and parotid glands, in an 82-year-old Japanese man. The resected tumor was solid nodular mass with fibrous capsule. The tumor was composed of papillary proliferation of tall columnar cells with thin vascular cores. The cytoplasm of the tumor cells was granular and eosinophilic. The tumor cells showed clear positive reaction for mitochondria and androgen receptor. GCDFP15 and HER2 were negative. Electron microscopy demonstrated numerous mitochondria in the cytoplasm of the tumor cells. Ki-67 index was 30%. Most of the tumor cells were positive for TP53, and single nucleotide polymorphism was found at codon 151. The invasion into the lymphatic spaces and capsule was noted. Although recurrence and metastasis were not noted at one and a half years after the resection, the patient needs to be followed up under careful observation. |
| first_indexed | 2024-12-19T04:09:12Z |
| format | Article |
| id | doaj.art-24c8f1077093455b8c2a39e508b97ec7 |
| institution | Directory Open Access Journal |
| issn | 2214-3300 |
| language | English |
| last_indexed | 2024-12-19T04:09:12Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology: Case Reports |
| spelling | doaj.art-24c8f1077093455b8c2a39e508b97ec72022-12-21T20:36:27ZengElsevierHuman Pathology: Case Reports2214-33002016-09-015C182210.1016/j.ehpc.2015.10.002A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumorShoko Kure, MD, PhD0Ryuichi Wada, MD, PhD1Wei-Xia Peng, MD, PhD2Hideaki Ishii, MD, PhD3Taeko Kitamura, MT4Takenori Fujii, MT5Shunta Inai, MD, PhD6Toshitaka Nagao, MD, PhD7Zenya Naito, MD, PhD8Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, JapanDepartment of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, JapanDepartment of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, JapanDepartment of Pathology, Nippon Medical School Hospital, Tokyo, 113-8602, JapanDepartment of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, JapanDepartment of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, JapanDepartment of Otolaryngology, Head and Neck Surgery, Nippon Medical School Hospital, Tokyo, 113-8602, JapanDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, 160-8402, JapanDepartment of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8602, JapanWe present histological, immunohistochemical and molecular features of oncocytic papillary cystadenocarcinoma, a rare neoplasm of the salivary and parotid glands, in an 82-year-old Japanese man. The resected tumor was solid nodular mass with fibrous capsule. The tumor was composed of papillary proliferation of tall columnar cells with thin vascular cores. The cytoplasm of the tumor cells was granular and eosinophilic. The tumor cells showed clear positive reaction for mitochondria and androgen receptor. GCDFP15 and HER2 were negative. Electron microscopy demonstrated numerous mitochondria in the cytoplasm of the tumor cells. Ki-67 index was 30%. Most of the tumor cells were positive for TP53, and single nucleotide polymorphism was found at codon 151. The invasion into the lymphatic spaces and capsule was noted. Although recurrence and metastasis were not noted at one and a half years after the resection, the patient needs to be followed up under careful observation.http://www.sciencedirect.com/science/article/pii/S2214330015300456Parotid glandCystadenocarcinomaMitochondriaAndrogen receptorTP53SNP |
| spellingShingle | Shoko Kure, MD, PhD Ryuichi Wada, MD, PhD Wei-Xia Peng, MD, PhD Hideaki Ishii, MD, PhD Taeko Kitamura, MT Takenori Fujii, MT Shunta Inai, MD, PhD Toshitaka Nagao, MD, PhD Zenya Naito, MD, PhD A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor Human Pathology: Case Reports Parotid gland Cystadenocarcinoma Mitochondria Androgen receptor TP53 SNP |
| title | A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor |
| title_full | A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor |
| title_fullStr | A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor |
| title_full_unstemmed | A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor |
| title_short | A case of oncocytic papillary cystadenocarcinoma of the parotid gland—Pathological and molecular features of a rare tumor |
| title_sort | case of oncocytic papillary cystadenocarcinoma of the parotid gland pathological and molecular features of a rare tumor |
| topic | Parotid gland Cystadenocarcinoma Mitochondria Androgen receptor TP53 SNP |
| url | http://www.sciencedirect.com/science/article/pii/S2214330015300456 |
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