Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations

Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations

Interleukin 15 (IL-15), a four-helix bundle cytokine, is involved in a plethora of different cellular functions and, particularly, plays a key role in the development and activation of immune responses. IL-15 forms receptor complexes by binding with IL-2Rβ- and common γ (γ...

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Bibliographic Details
Main Authors: Rui P. Sousa, Adèle D. Laurent, Agnès Quéméner, Erwan Mortier, Jean-Yves Le Questel
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
interleukin 15
IL-15 interfaces
molecular dynamics simulations
protein protein interactions
Online Access:https://www.mdpi.com/1420-3049/24/18/3261

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