Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis

Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis

Abstract Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and that FBXO22 knockdown increased the radiosensitivity of lung cancer cells. Mechan...

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Bibliografiske detaljer
Main Authors:	Yunshang Chen, Yun Zhou, Xue Feng, Zilong Wu, Yongqiang Yang, Xinrui Rao, Rui Zhou, Rui Meng, Xiaorong Dong, Shuangbing Xu, Sheng Zhang, Gang Wu, Xiaohua Jie
Format:	Article
Sprog:	English
Udgivet:	Nature Publishing Group 2024-01-01
Serier:	Cell Death and Disease
Online adgang:	https://doi.org/10.1038/s41419-024-06484-1

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