Advanced function, design and application of skin substitutes for skin regeneration
The development of skin substitutes aims to replace, mimic, or improve the functions of human skin, regenerate damaged skin tissue, and replace or enhance skin function. This includes artificial skin, scaffolds or devices designed for treatment, imitation, or improvement of skin function in wounds a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423003782 |
| _version_ | 1827381679440789504 |
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| author | Miao Zhang Jiyao Xing Yingjie Zhong Tingting Zhang Xinlin Liu Dongming Xing |
| author_facet | Miao Zhang Jiyao Xing Yingjie Zhong Tingting Zhang Xinlin Liu Dongming Xing |
| author_sort | Miao Zhang |
| collection | DOAJ |
| description | The development of skin substitutes aims to replace, mimic, or improve the functions of human skin, regenerate damaged skin tissue, and replace or enhance skin function. This includes artificial skin, scaffolds or devices designed for treatment, imitation, or improvement of skin function in wounds and injuries. Therefore, tremendous efforts have been made to develop functional skin substitutes. However, there is still few reports systematically discuss the relationship between the advanced function and design requirements. In this paper, we review the classification, functions, and design requirements of artificial skin or skin substitutes. Different manufacturing strategies for skin substitutes such as hydrogels, 3D/4D printing, electrospinning, microfluidics are summarized. This review also introduces currently available skin substitutes in clinical trials and on the market and the related regulatory requirements. Finally, the prospects and challenges of skin substitutes in the field of tissue engineering are discussed. |
| first_indexed | 2024-03-08T14:07:45Z |
| format | Article |
| id | doaj.art-24cdb68090a441d0a371d4f962680874 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-08T14:07:45Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-24cdb68090a441d0a371d4f9626808742024-01-15T04:24:01ZengElsevierMaterials Today Bio2590-00642024-02-0124100918Advanced function, design and application of skin substitutes for skin regenerationMiao Zhang0Jiyao Xing1Yingjie Zhong2Tingting Zhang3Xinlin Liu4Dongming Xing5The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Cancer Institute, Qingdao University, Qingdao 266071, ChinaThe Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Cancer Institute, Qingdao University, Qingdao 266071, ChinaThe Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Cancer Institute, Qingdao University, Qingdao 266071, ChinaThe Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Cancer Institute, Qingdao University, Qingdao 266071, ChinaThe Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Cancer Institute, Qingdao University, Qingdao 266071, China; Corresponding author. The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China; Cancer Institute, Qingdao University, Qingdao 266071, China; School of Life Sciences, Tsinghua University, Beijing 100084, China; Corresponding author. The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, China.The development of skin substitutes aims to replace, mimic, or improve the functions of human skin, regenerate damaged skin tissue, and replace or enhance skin function. This includes artificial skin, scaffolds or devices designed for treatment, imitation, or improvement of skin function in wounds and injuries. Therefore, tremendous efforts have been made to develop functional skin substitutes. However, there is still few reports systematically discuss the relationship between the advanced function and design requirements. In this paper, we review the classification, functions, and design requirements of artificial skin or skin substitutes. Different manufacturing strategies for skin substitutes such as hydrogels, 3D/4D printing, electrospinning, microfluidics are summarized. This review also introduces currently available skin substitutes in clinical trials and on the market and the related regulatory requirements. Finally, the prospects and challenges of skin substitutes in the field of tissue engineering are discussed.http://www.sciencedirect.com/science/article/pii/S2590006423003782Skin substitutesArtificial skinDesign strategyManufacturing methodsSkin regeneration |
| spellingShingle | Miao Zhang Jiyao Xing Yingjie Zhong Tingting Zhang Xinlin Liu Dongming Xing Advanced function, design and application of skin substitutes for skin regeneration Materials Today Bio Skin substitutes Artificial skin Design strategy Manufacturing methods Skin regeneration |
| title | Advanced function, design and application of skin substitutes for skin regeneration |
| title_full | Advanced function, design and application of skin substitutes for skin regeneration |
| title_fullStr | Advanced function, design and application of skin substitutes for skin regeneration |
| title_full_unstemmed | Advanced function, design and application of skin substitutes for skin regeneration |
| title_short | Advanced function, design and application of skin substitutes for skin regeneration |
| title_sort | advanced function design and application of skin substitutes for skin regeneration |
| topic | Skin substitutes Artificial skin Design strategy Manufacturing methods Skin regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423003782 |
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