Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegans
With the rapid development of magnetic technology, the biological effects of moderate static magnetic fields (SMFs) have attracted increasing research interest due to their potential medical diagnosis and treatment application. The present study explored the effects of moderate SMFs on the lipid met...
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Elsevier
2023-07-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323005092 |
| _version_ | 1797812778202824704 |
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| author | Zicheng Liu Lei Cheng Baolin Yang Zhenxiao Cao Meng Sun Yu Feng An Xu |
| author_facet | Zicheng Liu Lei Cheng Baolin Yang Zhenxiao Cao Meng Sun Yu Feng An Xu |
| author_sort | Zicheng Liu |
| collection | DOAJ |
| description | With the rapid development of magnetic technology, the biological effects of moderate static magnetic fields (SMFs) have attracted increasing research interest due to their potential medical diagnosis and treatment application. The present study explored the effects of moderate SMFs on the lipid metabolism of Caenorhabditis elegans (C. elegans) in different genders including male, female, and hermaphrodite. We found that the fat content was significantly decreased by moderate SMFs in wild-type N2 worms, which was associated with their development stages. The diameters of lipid droplets in N2 worms, him-5 worms, and fog-2 worms were greatly decreased by 19.23%, 15.38%, and 23.07% at young adult stage under 0.5 T SMF, respectively. The mRNA levels of lipolysis related genes atgl-1 and nhr-76 were significantly up-regulated by SMF exposure, while the mRNA levels of the lipogenesis related genes fat-6, fat-7, and sbp-1 were down-regulated by SMF, whereas the concentration of β-oxidase was increased. There was a slight effect of SMF on the mRNA levels of β-oxidation related genes. Moreover, the insulin and serotonin pathway were regulated by SMF, instead of the TOR pathway. In wild-type worms, we found that their lifespan was prolonged by exposure to 0.5 T SMF. Our data suggested that moderate SMFs could significantly modify the lipogenesis and lipolysis process in C. elegans in a gender and development stage-dependent manner, which could provide a novel insight into understanding the function of moderate SMFs in living organisms. |
| first_indexed | 2024-03-13T07:43:30Z |
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| id | doaj.art-24ce29854a7d42bf924a4c73d5f2f473 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-13T07:43:30Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-24ce29854a7d42bf924a4c73d5f2f4732023-06-03T04:21:25ZengElsevierEcotoxicology and Environmental Safety0147-65132023-07-01259115005Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegansZicheng Liu0Lei Cheng1Baolin Yang2Zhenxiao Cao3Meng Sun4Yu Feng5An Xu6School of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei, Anhui 230031, China; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui 230031, ChinaSchool of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei, Anhui 230031, China; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui 230031, ChinaSchool of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei, Anhui 230031, China; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui 230031, ChinaSchool of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei, Anhui 230031, China; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui 230031, ChinaKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei, Anhui 230031, China; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui 230031, ChinaKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei, Anhui 230031, China; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui 230031, ChinaSchool of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, China; Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei, Anhui 230031, China; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui 230031, China; Correspondence to: Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, Hefei, Anhui 230031, China.With the rapid development of magnetic technology, the biological effects of moderate static magnetic fields (SMFs) have attracted increasing research interest due to their potential medical diagnosis and treatment application. The present study explored the effects of moderate SMFs on the lipid metabolism of Caenorhabditis elegans (C. elegans) in different genders including male, female, and hermaphrodite. We found that the fat content was significantly decreased by moderate SMFs in wild-type N2 worms, which was associated with their development stages. The diameters of lipid droplets in N2 worms, him-5 worms, and fog-2 worms were greatly decreased by 19.23%, 15.38%, and 23.07% at young adult stage under 0.5 T SMF, respectively. The mRNA levels of lipolysis related genes atgl-1 and nhr-76 were significantly up-regulated by SMF exposure, while the mRNA levels of the lipogenesis related genes fat-6, fat-7, and sbp-1 were down-regulated by SMF, whereas the concentration of β-oxidase was increased. There was a slight effect of SMF on the mRNA levels of β-oxidation related genes. Moreover, the insulin and serotonin pathway were regulated by SMF, instead of the TOR pathway. In wild-type worms, we found that their lifespan was prolonged by exposure to 0.5 T SMF. Our data suggested that moderate SMFs could significantly modify the lipogenesis and lipolysis process in C. elegans in a gender and development stage-dependent manner, which could provide a novel insight into understanding the function of moderate SMFs in living organisms.http://www.sciencedirect.com/science/article/pii/S0147651323005092Moderate static magnetic fieldsC. elegansLipogenesis and lipolysisGenderSignaling pathway |
| spellingShingle | Zicheng Liu Lei Cheng Baolin Yang Zhenxiao Cao Meng Sun Yu Feng An Xu Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegans Ecotoxicology and Environmental Safety Moderate static magnetic fields C. elegans Lipogenesis and lipolysis Gender Signaling pathway |
| title | Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegans |
| title_full | Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegans |
| title_fullStr | Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegans |
| title_full_unstemmed | Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegans |
| title_short | Effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of Caenorhabditis elegans |
| title_sort | effects of moderate static magnetic fields on the lipogenesis and lipolysis in different genders of caenorhabditis elegans |
| topic | Moderate static magnetic fields C. elegans Lipogenesis and lipolysis Gender Signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323005092 |
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