p53 and the Viral Connection: Back into the Future ‡
The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/10/6/178 |
| _version_ | 1797766357568192512 |
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| author | Ronit Aloni-Grinstein Meital Charni-Natan Hilla Solomon Varda Rotter |
| author_facet | Ronit Aloni-Grinstein Meital Charni-Natan Hilla Solomon Varda Rotter |
| author_sort | Ronit Aloni-Grinstein |
| collection | DOAJ |
| description | The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Viruses have learned to manipulate WTp53 through different strategies to improve their replication and spreading in a stage-specific, bidirectional way. While some viruses require active WTp53 for efficient viral replication, others require reduction/inhibition of WTp53 activity. A better understanding of WTp53 functionality in viral life may offer new future clinical approaches, based on WTp53 manipulation, for viral infections. |
| first_indexed | 2024-03-12T20:24:06Z |
| format | Article |
| id | doaj.art-24ce9e2a26a24c598ef5014a72823929 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:24:06Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-24ce9e2a26a24c598ef5014a728239292023-08-02T00:38:33ZengMDPI AGCancers2072-66942018-06-0110617810.3390/cancers10060178cancers10060178p53 and the Viral Connection: Back into the Future ‡Ronit Aloni-Grinstein0Meital Charni-Natan1Hilla Solomon2Varda Rotter3Department of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, IsraelDepartment of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, IsraelDepartment of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, IsraelDepartment of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, IsraelThe discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Viruses have learned to manipulate WTp53 through different strategies to improve their replication and spreading in a stage-specific, bidirectional way. While some viruses require active WTp53 for efficient viral replication, others require reduction/inhibition of WTp53 activity. A better understanding of WTp53 functionality in viral life may offer new future clinical approaches, based on WTp53 manipulation, for viral infections.http://www.mdpi.com/2072-6694/10/6/178virusp53cancerSV40papillomazikainfluenzaHIV-1HSV-1vaccinia |
| spellingShingle | Ronit Aloni-Grinstein Meital Charni-Natan Hilla Solomon Varda Rotter p53 and the Viral Connection: Back into the Future ‡ Cancers virus p53 cancer SV40 papilloma zika influenza HIV-1 HSV-1 vaccinia |
| title | p53 and the Viral Connection: Back into the Future ‡ |
| title_full | p53 and the Viral Connection: Back into the Future ‡ |
| title_fullStr | p53 and the Viral Connection: Back into the Future ‡ |
| title_full_unstemmed | p53 and the Viral Connection: Back into the Future ‡ |
| title_short | p53 and the Viral Connection: Back into the Future ‡ |
| title_sort | p53 and the viral connection back into the future ‡ |
| topic | virus p53 cancer SV40 papilloma zika influenza HIV-1 HSV-1 vaccinia |
| url | http://www.mdpi.com/2072-6694/10/6/178 |
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