Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus
A 26-year-old Chinese male consulted with the team regarding his alopecia areata and vitiligo for which previous treatment was ineffective. The patient, a homosexual man, denied having a history of drug abuse and of blood transfusion. No member of his family had vitiligo or alopecia. Laboratory stud...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2014;volume=59;issue=2;spage=209;epage=209;aulast=Xuan |
| _version_ | 1819265228000460800 |
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| author | Li Xuan Yang Baohua Baohua Lan |
| author_facet | Li Xuan Yang Baohua Baohua Lan |
| author_sort | Li Xuan |
| collection | DOAJ |
| description | A 26-year-old Chinese male consulted with the team regarding his alopecia areata and vitiligo for which previous treatment was ineffective. The patient, a homosexual man, denied having a history of drug abuse and of blood transfusion. No member of his family had vitiligo or alopecia. Laboratory studies revealed that the serum for anti-human immunodeficiency virus (HIV) antibody was positive. The patient′s CD4 lymphocyte count and CD4/CD8 ratio were both strikingly low (20 cells/mL and 0.04), but no other complaints or opportunistic infections were reported. One month after antiretroviral therapy, the patient′s alopecia areata dramatically improved, but no evident improvement in his vitiligo was found. This case is a very rare case of alopecia areata and vitiligo associated with HIV infection that might be attributed to the generation and maintenance of self-reactive CD8+ T-cells due to chronic immune activation with progressive immune exhaustion in HIV infection. |
| first_indexed | 2024-12-23T20:42:02Z |
| format | Article |
| id | doaj.art-24d0278ffb524c02838431a4e7bab3ec |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-23T20:42:02Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-24d0278ffb524c02838431a4e7bab3ec2022-12-21T17:31:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112014-01-0159220920910.4103/0019-5154.127710Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virusLi XuanYang BaohuaBaohua LanA 26-year-old Chinese male consulted with the team regarding his alopecia areata and vitiligo for which previous treatment was ineffective. The patient, a homosexual man, denied having a history of drug abuse and of blood transfusion. No member of his family had vitiligo or alopecia. Laboratory studies revealed that the serum for anti-human immunodeficiency virus (HIV) antibody was positive. The patient′s CD4 lymphocyte count and CD4/CD8 ratio were both strikingly low (20 cells/mL and 0.04), but no other complaints or opportunistic infections were reported. One month after antiretroviral therapy, the patient′s alopecia areata dramatically improved, but no evident improvement in his vitiligo was found. This case is a very rare case of alopecia areata and vitiligo associated with HIV infection that might be attributed to the generation and maintenance of self-reactive CD8+ T-cells due to chronic immune activation with progressive immune exhaustion in HIV infection.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2014;volume=59;issue=2;spage=209;epage=209;aulast=XuanAcquired immune deficiency syndromealopecia areatahuman immunodeficiency virusvitiligo |
| spellingShingle | Li Xuan Yang Baohua Baohua Lan Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus Indian Journal of Dermatology Acquired immune deficiency syndrome alopecia areata human immunodeficiency virus vitiligo |
| title | Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus |
| title_full | Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus |
| title_fullStr | Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus |
| title_full_unstemmed | Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus |
| title_short | Alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus |
| title_sort | alopecia areata and vitiligo as primary presentations in a young male with human immunodeficiency virus |
| topic | Acquired immune deficiency syndrome alopecia areata human immunodeficiency virus vitiligo |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2014;volume=59;issue=2;spage=209;epage=209;aulast=Xuan |
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