Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals
Regular physical activity may promote beneficial neuroplasticity, e.g., increased hippocampus volume. However, it is unclear whether self-reported physical exercise in leisure (PEL) levels are associated with the brain structure features demonstrated by exercise interventions. This pilot study inves...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Epilepsy & Behavior Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589986423000618 |
| _version_ | 1797281176707137536 |
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| author | Ayushe A. Sharma D. Mackensie Terry Johanna L. Popp Jerzy P. Szaflarski Roy C. Martin Rodolphe Nenert Manmeet Kaur Gabrielle A. Brokamp Mark Bolding Jane B. Allendorfer |
| author_facet | Ayushe A. Sharma D. Mackensie Terry Johanna L. Popp Jerzy P. Szaflarski Roy C. Martin Rodolphe Nenert Manmeet Kaur Gabrielle A. Brokamp Mark Bolding Jane B. Allendorfer |
| author_sort | Ayushe A. Sharma |
| collection | DOAJ |
| description | Regular physical activity may promote beneficial neuroplasticity, e.g., increased hippocampus volume. However, it is unclear whether self-reported physical exercise in leisure (PEL) levels are associated with the brain structure features demonstrated by exercise interventions. This pilot study investigated the relationship between PEL, mood, cognition, and neuromorphometry in patients with idiopathic generalized epilepsy (IGEs) compared to healthy controls (HCs). Seventeen IGEs and 19 age- and sex-matched HCs underwent magnetic resonance imaging (MRI) at 3T. The Baecke Questionnaire of Habitual Physical Activity, Profile of Mood States, and Montreal Cognitive Assessment (MoCA) assessed PEL, mood, and cognition, respectively. Structural MRI data were analyzed by voxel- and surface-based morphometry. IGEs had significantly lower PEL (p < 0.001), poorer mood (p = 0.029), and lower MoCA scores (p = 0.027) than HCs. These group differences were associated with reduced volume, decreased gyrification, and altered surface topology (IGEs < HCs) in frontal, temporal and cerebellar regions involved in executive function, memory retrieval, and emotional regulation, respectively.These preliminary results support the notion that increased PEL may promote neuroplasticity in IGEs, thus emphasizing the role of physical activity in promoting brain health in people with epilepsy. |
| first_indexed | 2024-03-07T16:52:50Z |
| format | Article |
| id | doaj.art-24d1c84a4a7847608183f0b4b723aabd |
| institution | Directory Open Access Journal |
| issn | 2589-9864 |
| language | English |
| last_indexed | 2024-03-07T16:52:50Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy & Behavior Reports |
| spelling | doaj.art-24d1c84a4a7847608183f0b4b723aabd2024-03-03T04:30:05ZengElsevierEpilepsy & Behavior Reports2589-98642024-01-0125100643Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individualsAyushe A. Sharma0D. Mackensie Terry1Johanna L. Popp2Jerzy P. Szaflarski3Roy C. Martin4Rodolphe Nenert5Manmeet Kaur6Gabrielle A. Brokamp7Mark Bolding8Jane B. Allendorfer9University of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USA; Corresponding authors at: UAB Epilepsy Center, University of Alabama at Birmingham, Department of Neurology, 1719 6th Avenue South, CIRC 312, Birmingham, AL 35249-0021, USA.University of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), Department of Neurobiology, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), Department of Neurosurgery, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), UAB Epilepsy Center, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), UAB Epilepsy Center, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), UAB Epilepsy Center, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Radiology, Birmingham, AL, USAUniversity of Alabama at Birmingham (UAB), Department of Neurology, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), Department of Neurobiology, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), UAB Epilepsy Center, Birmingham, AL, USA; University of Alabama at Birmingham (UAB), UAB Center for Exercise Medicine, Birmingham, AL, USA; Corresponding authors at: UAB Epilepsy Center, University of Alabama at Birmingham, Department of Neurology, 1719 6th Avenue South, CIRC 312, Birmingham, AL 35249-0021, USA.Regular physical activity may promote beneficial neuroplasticity, e.g., increased hippocampus volume. However, it is unclear whether self-reported physical exercise in leisure (PEL) levels are associated with the brain structure features demonstrated by exercise interventions. This pilot study investigated the relationship between PEL, mood, cognition, and neuromorphometry in patients with idiopathic generalized epilepsy (IGEs) compared to healthy controls (HCs). Seventeen IGEs and 19 age- and sex-matched HCs underwent magnetic resonance imaging (MRI) at 3T. The Baecke Questionnaire of Habitual Physical Activity, Profile of Mood States, and Montreal Cognitive Assessment (MoCA) assessed PEL, mood, and cognition, respectively. Structural MRI data were analyzed by voxel- and surface-based morphometry. IGEs had significantly lower PEL (p < 0.001), poorer mood (p = 0.029), and lower MoCA scores (p = 0.027) than HCs. These group differences were associated with reduced volume, decreased gyrification, and altered surface topology (IGEs < HCs) in frontal, temporal and cerebellar regions involved in executive function, memory retrieval, and emotional regulation, respectively.These preliminary results support the notion that increased PEL may promote neuroplasticity in IGEs, thus emphasizing the role of physical activity in promoting brain health in people with epilepsy.http://www.sciencedirect.com/science/article/pii/S2589986423000618HippocampusGrey matter volumeExercise levelsIdiopathic generalized epilepsyMoodCognition |
| spellingShingle | Ayushe A. Sharma D. Mackensie Terry Johanna L. Popp Jerzy P. Szaflarski Roy C. Martin Rodolphe Nenert Manmeet Kaur Gabrielle A. Brokamp Mark Bolding Jane B. Allendorfer Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals Epilepsy & Behavior Reports Hippocampus Grey matter volume Exercise levels Idiopathic generalized epilepsy Mood Cognition |
| title | Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals |
| title_full | Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals |
| title_fullStr | Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals |
| title_full_unstemmed | Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals |
| title_short | Neuromorphometric associations with mood, cognition, and self-reported exercise levels in epilepsy and healthy individuals |
| title_sort | neuromorphometric associations with mood cognition and self reported exercise levels in epilepsy and healthy individuals |
| topic | Hippocampus Grey matter volume Exercise levels Idiopathic generalized epilepsy Mood Cognition |
| url | http://www.sciencedirect.com/science/article/pii/S2589986423000618 |
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