Rare but possible: clopidogrel-induced pancytopenia
We present the case of an 84-year-old female patient admitted to the Internal Medicine Ward for atypical chest pain and laboratory findings of severe pancytopenia. Past medical history was remarkable for an episode of myocardial infarction approximately 4 weeks prior to the current hospitalization...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-10-01
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| Series: | Italian Journal of Medicine |
| Subjects: | |
| Online Access: | https://italjmed.org/index.php/ijm/article/view/1660 |
| _version_ | 1827606697201369088 |
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| author | Pietro Bocchi Pasquale Gianluca Giuri Achiropita Bovino Alessia Casola Simona Detrenis Marcello Bertorelli Michele Meschi Giancarlo Mangè |
| author_facet | Pietro Bocchi Pasquale Gianluca Giuri Achiropita Bovino Alessia Casola Simona Detrenis Marcello Bertorelli Michele Meschi Giancarlo Mangè |
| author_sort | Pietro Bocchi |
| collection | DOAJ |
| description |
We present the case of an 84-year-old female patient admitted to the Internal Medicine Ward for atypical chest pain and laboratory findings of severe pancytopenia. Past medical history was remarkable for an episode of myocardial infarction approximately 4 weeks prior to the current hospitalization which had required angioplasty + drug-eluting stent and dual antiplatelet therapy with acetylsalicylic acid and clopidogrel. Some rare cases of clopidogrel-induced pancytopenia are described in scientific literature, therefore, after excluding infectious, vitamin deficiencies, and autoimmune causes, we modified the antiplatelet therapy by replacing clopidogrel with ticagrelor, obtaining complete leukocyte recovery within a few days. Since clopidogrel is an antiplatelet drug still used in clinical cardiological practice, the knowledge of this rare side effect may lead the clinician to suspect hematological toxicity which, if recognized promptly, may suggest modification of antiplatelet therapy and limit any possible infectious complications for the care of the patient.
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| first_indexed | 2024-03-09T06:42:03Z |
| format | Article |
| id | doaj.art-24d7574ecc0442a0ab303978c54f14be |
| institution | Directory Open Access Journal |
| issn | 1877-9344 1877-9352 |
| language | English |
| last_indexed | 2024-03-09T06:42:03Z |
| publishDate | 2023-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj.art-24d7574ecc0442a0ab303978c54f14be2023-12-03T10:46:51ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522023-10-0117310.4081/itjm.2023.1660Rare but possible: clopidogrel-induced pancytopeniaPietro Bocchi0Pasquale Gianluca Giuri1Achiropita Bovino2Alessia Casola3Simona Detrenis4Marcello Bertorelli5Michele Meschi6Giancarlo Mangè7Department of Internal Medicine, Vaio Hospital, Fidenza (PR)Department of Internal Medicine, Santa Maria Hospital, Borgo Val di Taro (PR)Department of Internal Medicine, Vaio Hospital, Fidenza (PR)Department of Internal Medicine, Vaio Hospital, Fidenza (PR)Department of Internal Medicine, Santa Maria Hospital, Borgo Val di Taro (PR)Department of Clinical Cardiology, Cardiologic Rehabilitation and High Care Ward, Santa Maria Hospital, Borgo Val di Taro (PR)Department of Internal Medicine, Vaio Hospital, Fidenza (PR)Department of Internal Medicine, Vaio Hospital, Fidenza (PR) We present the case of an 84-year-old female patient admitted to the Internal Medicine Ward for atypical chest pain and laboratory findings of severe pancytopenia. Past medical history was remarkable for an episode of myocardial infarction approximately 4 weeks prior to the current hospitalization which had required angioplasty + drug-eluting stent and dual antiplatelet therapy with acetylsalicylic acid and clopidogrel. Some rare cases of clopidogrel-induced pancytopenia are described in scientific literature, therefore, after excluding infectious, vitamin deficiencies, and autoimmune causes, we modified the antiplatelet therapy by replacing clopidogrel with ticagrelor, obtaining complete leukocyte recovery within a few days. Since clopidogrel is an antiplatelet drug still used in clinical cardiological practice, the knowledge of this rare side effect may lead the clinician to suspect hematological toxicity which, if recognized promptly, may suggest modification of antiplatelet therapy and limit any possible infectious complications for the care of the patient. https://italjmed.org/index.php/ijm/article/view/1660Clopidogrelneutropeniamyocardial infarctionadverse drug reaction |
| spellingShingle | Pietro Bocchi Pasquale Gianluca Giuri Achiropita Bovino Alessia Casola Simona Detrenis Marcello Bertorelli Michele Meschi Giancarlo Mangè Rare but possible: clopidogrel-induced pancytopenia Italian Journal of Medicine Clopidogrel neutropenia myocardial infarction adverse drug reaction |
| title | Rare but possible: clopidogrel-induced pancytopenia |
| title_full | Rare but possible: clopidogrel-induced pancytopenia |
| title_fullStr | Rare but possible: clopidogrel-induced pancytopenia |
| title_full_unstemmed | Rare but possible: clopidogrel-induced pancytopenia |
| title_short | Rare but possible: clopidogrel-induced pancytopenia |
| title_sort | rare but possible clopidogrel induced pancytopenia |
| topic | Clopidogrel neutropenia myocardial infarction adverse drug reaction |
| url | https://italjmed.org/index.php/ijm/article/view/1660 |
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