NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation

NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation

2B4 (CD244) and NK-T-B-antigen (NTB-A, CD352) are activating receptors on human NK cells and belong to the family of SLAM-related receptors. Engagement of these receptors leads to phosphorylation of their cytoplasmic tails and recruitment of the adapter proteins SAP and EAT-2. X-linked lymphoprolife...

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Bibliographic Details
Main Authors: Stephan eMeinke, Carsten eWatzl
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Immunology
Subjects:
human
Cytotoxicity
Natural Killer cells
Cell activation
Cell surface molecules
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00003/full

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