Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity

Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity

The leptin receptor (LepR) acts as a signaling nexus for the regulation of glucose uptake and obesity, among other metabolic responses. The functional role of LepR under leptin-deficient conditions remains unclear. This study reports that epiregulin (EREG) governed glucose uptake in vitro and in viv...

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Detalles Bibliográficos
Main Authors: No-Joon Song, Aejin Lee, Rumana Yasmeen, Qiwen Shen, Kefeng Yang, Shashi Bhushan Kumar, Danah Muhanna, Shanvanth Arnipalli, Sabrena F. Noria, Bradley J. Needleman, Jeffrey W. Hazey, Dean J. Mikami, Joana Ortega-Anaya, Rafael Jiménez-Flores, Jeremy Prokop, Ouliana Ziouzenkova
Formato: Artigo
Idioma:English
Publicado: MDPI AG 2022-01-01
Series:Cells
Subjects:
epiregulin
leptin receptor
ERK
EGFR
glucose uptake
energy metabolism
Acceso en liña:https://www.mdpi.com/2073-4409/11/3/425

Internet

https://www.mdpi.com/2073-4409/11/3/425

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