Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment
Ferroptosis is a newly proposed programmed cell death that has great potential in limiting tumor progression and malignancies that are resistant to conventional therapies. However, recent reports have shown that ferroptosis in the tumor microenvironment can provide a favorable environment to promote...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.868639/full |
| _version_ | 1818335062604644352 |
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| author | Qing Bi Qing Bi Ze-jia Sun Ze-jia Sun Ji-yue Wu Ji-yue Wu Wei Wang Wei Wang |
| author_facet | Qing Bi Qing Bi Ze-jia Sun Ze-jia Sun Ji-yue Wu Ji-yue Wu Wei Wang Wei Wang |
| author_sort | Qing Bi |
| collection | DOAJ |
| description | Ferroptosis is a newly proposed programmed cell death that has great potential in limiting tumor progression and malignancies that are resistant to conventional therapies. However, recent reports have shown that ferroptosis in the tumor microenvironment can provide a favorable environment to promote tumor survival and progression, which is induced by the infiltration and polarization of pro-tumor immune cells and the dysfunction of anti-tumor immunity. In this mini-review, we introduce the mechanisms of ferroptosis, describe the crosstalk between ferroptosis and cancer, demonstrate the potential ways in which ferroptosis shapes the pro-tumor immune microenvironment, and present our thoughts on ferroptosis-based cancer therapies. |
| first_indexed | 2024-12-13T14:17:27Z |
| format | Article |
| id | doaj.art-24d92637862f4f5cbe8816a11d838f9f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T14:17:27Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-24d92637862f4f5cbe8816a11d838f9f2022-12-21T23:42:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.868639868639Ferroptosis-Mediated Formation of Tumor-Promoting Immune MicroenvironmentQing Bi0Qing Bi1Ze-jia Sun2Ze-jia Sun3Ji-yue Wu4Ji-yue Wu5Wei Wang6Wei Wang7Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaInstitute of Urology, Capital Medical University, Beijing, ChinaFerroptosis is a newly proposed programmed cell death that has great potential in limiting tumor progression and malignancies that are resistant to conventional therapies. However, recent reports have shown that ferroptosis in the tumor microenvironment can provide a favorable environment to promote tumor survival and progression, which is induced by the infiltration and polarization of pro-tumor immune cells and the dysfunction of anti-tumor immunity. In this mini-review, we introduce the mechanisms of ferroptosis, describe the crosstalk between ferroptosis and cancer, demonstrate the potential ways in which ferroptosis shapes the pro-tumor immune microenvironment, and present our thoughts on ferroptosis-based cancer therapies.https://www.frontiersin.org/articles/10.3389/fonc.2022.868639/fullferroptosiscell deathtumor microenvironmentimmune escapetumor progressimmune microenvironment |
| spellingShingle | Qing Bi Qing Bi Ze-jia Sun Ze-jia Sun Ji-yue Wu Ji-yue Wu Wei Wang Wei Wang Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment Frontiers in Oncology ferroptosis cell death tumor microenvironment immune escape tumor progress immune microenvironment |
| title | Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment |
| title_full | Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment |
| title_fullStr | Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment |
| title_full_unstemmed | Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment |
| title_short | Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment |
| title_sort | ferroptosis mediated formation of tumor promoting immune microenvironment |
| topic | ferroptosis cell death tumor microenvironment immune escape tumor progress immune microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.868639/full |
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