Treatment and long-term follow-up of primary CNS classical Hodgkin's lymphoma – A case report and review of the literature

Unlike non-Hodgkin's lymphoma, central nervous system involvement with classical Hodgkin's lymphoma is exceedingly rare, thus information regarding treatment and prognostication of the disease is lacking. We present the case of a 47 year old female who presented with a left parietal dural-...

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Bibliographic Details
Main Authors: Paul A. Szelemej, Mark G. Bigder, Jerry Krcek
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Interdisciplinary Neurosurgery
Online Access:http://www.sciencedirect.com/science/article/pii/S2214751917300142
Description
Summary:Unlike non-Hodgkin's lymphoma, central nervous system involvement with classical Hodgkin's lymphoma is exceedingly rare, thus information regarding treatment and prognostication of the disease is lacking. We present the case of a 47 year old female who presented with a left parietal dural-based lesion which proved to be Stage IE primary CNS classical Hodgkin's lymphoma. After surgery and whole brain radiation therapy, the patient has remained in complete remission over nine years. Despite the dearth of information available regarding CNS Hodgkin's lymphoma, our case is consistent with the findings in the literature that long-term survival is possible in patients achieving a complete response to treatment, especially in those patients who present with sole CNS involvement. To our knowledge, this represents the longest reported survival in the literature and contributes to our understanding of prognosis in patients with CNS Hodgkin's lymphoma. Keywords: Classical Hodgkin's lymphoma, Long-term survival, CNS lymphoma
ISSN:2214-7519