Caudal Regression Syndrome
Caudal Regression Syndrome (CRS) or Caudal dysgenesis syndrome (CDS) is characterized by maldevelopment of the caudal half of the body with variable involvement of the gastrointestinal, genitourinary, skeletal, and nervous systems. CRS affects 1–3 newborn infants per 100,000 live births. The prevale...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/7/11/211 |
| _version_ | 1797548793862815744 |
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| author | Ranjit I. Kylat Mohammad Bader |
| author_facet | Ranjit I. Kylat Mohammad Bader |
| author_sort | Ranjit I. Kylat |
| collection | DOAJ |
| description | Caudal Regression Syndrome (CRS) or Caudal dysgenesis syndrome (CDS) is characterized by maldevelopment of the caudal half of the body with variable involvement of the gastrointestinal, genitourinary, skeletal, and nervous systems. CRS affects 1–3 newborn infants per 100,000 live births. The prevalence in infants of diabetic mothers is reported at 1 in 350 live births which includes all the variants. A related condition is sirenomelia sequence or mermaid syndrome or symmelia and is characterized by fusion of the legs and a variable combination of the other abnormalities. The Currarino triad is a related anomaly that includes anorectal atresia, coccygeal and partial sacral agenesis, and a pre-sacral lesion such as anterior meningocele, lipoma or dermoid cyst. A multidisciplinary management approach is needed that includes rehabilitative services, and patients need a staged surgical approach. |
| first_indexed | 2024-03-10T15:04:49Z |
| format | Article |
| id | doaj.art-24db598732634ddbb1017a4980ea9df7 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T15:04:49Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-24db598732634ddbb1017a4980ea9df72023-11-20T19:49:31ZengMDPI AGChildren2227-90672020-11-0171121110.3390/children7110211Caudal Regression SyndromeRanjit I. Kylat0Mohammad Bader1Department of Pediatrics, University of Arizona, College of Medicine, Tucson, AZ 85724, USADepartment of Pediatrics, University of Arizona, College of Medicine, Tucson, AZ 85724, USACaudal Regression Syndrome (CRS) or Caudal dysgenesis syndrome (CDS) is characterized by maldevelopment of the caudal half of the body with variable involvement of the gastrointestinal, genitourinary, skeletal, and nervous systems. CRS affects 1–3 newborn infants per 100,000 live births. The prevalence in infants of diabetic mothers is reported at 1 in 350 live births which includes all the variants. A related condition is sirenomelia sequence or mermaid syndrome or symmelia and is characterized by fusion of the legs and a variable combination of the other abnormalities. The Currarino triad is a related anomaly that includes anorectal atresia, coccygeal and partial sacral agenesis, and a pre-sacral lesion such as anterior meningocele, lipoma or dermoid cyst. A multidisciplinary management approach is needed that includes rehabilitative services, and patients need a staged surgical approach.https://www.mdpi.com/2227-9067/7/11/211caudal dysgenesis syndromecaudal regression syndromesirenomelia |
| spellingShingle | Ranjit I. Kylat Mohammad Bader Caudal Regression Syndrome Children caudal dysgenesis syndrome caudal regression syndrome sirenomelia |
| title | Caudal Regression Syndrome |
| title_full | Caudal Regression Syndrome |
| title_fullStr | Caudal Regression Syndrome |
| title_full_unstemmed | Caudal Regression Syndrome |
| title_short | Caudal Regression Syndrome |
| title_sort | caudal regression syndrome |
| topic | caudal dysgenesis syndrome caudal regression syndrome sirenomelia |
| url | https://www.mdpi.com/2227-9067/7/11/211 |
| work_keys_str_mv | AT ranjitikylat caudalregressionsyndrome AT mohammadbader caudalregressionsyndrome |