Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern China
ABSTRACT: Intestinal Talaromyces marneffei (TM) infection among patients with HIV/AIDS is rare. Herein, we report 31 cases of intestinal TM infection in Guangxi. Most patients exhibited fever, lymphadenectasis in the abdominal cavity, and chronic intestinal symptoms. CD4+ T-cell counts <50 cells/...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222001965 |
| _version_ | 1818208604044394496 |
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| author | Zhiman Xie Jingzhen Lai Renping Peng Minhong Mou Hao Liang Chuanyi Ning |
| author_facet | Zhiman Xie Jingzhen Lai Renping Peng Minhong Mou Hao Liang Chuanyi Ning |
| author_sort | Zhiman Xie |
| collection | DOAJ |
| description | ABSTRACT: Intestinal Talaromyces marneffei (TM) infection among patients with HIV/AIDS is rare. Herein, we report 31 cases of intestinal TM infection in Guangxi. Most patients exhibited fever, lymphadenectasis in the abdominal cavity, and chronic intestinal symptoms. CD4+ T-cell counts <50 cells/μL were reported in 28 patients. TM was cultured from the blood of 23 patients and from the marrow of 7 patients, whereas TM-like fungal spores in the cytoplasm of tissues with erosion, ulceration, and/or polyps were found in all 31 patients. We suggest that intestinal TM infection should be considered among patients infected with HIV with extremely low CD4+ T-cell counts (<50 cells/μL) who are manifesting fever, chronic gastrointestinal symptoms, and endoscopic evidence of erosion and/or ulceration. |
| first_indexed | 2024-12-12T04:47:27Z |
| format | Article |
| id | doaj.art-24de57cd4d7d466ab80b6934f77dab01 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T04:47:27Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-24de57cd4d7d466ab80b6934f77dab012022-12-22T00:37:35ZengElsevierInternational Journal of Infectious Diseases1201-97122022-07-011204850Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern ChinaZhiman Xie0Jingzhen Lai1Renping Peng2Minhong Mou3Hao Liang4Chuanyi Ning5No. 4th People's Hospital of Nanning and the Affiliated Nanning Infectious Diseases Hospital of Guangxi Medical University, Guangxi Medical University, No. 1, Second Lane, Changgang Road, Nanning, Guangxi 530023, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi 530021, China; Guangxi Biobank, Life Sciences Institute, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi 530021, ChinaNo. 4th People's Hospital of Nanning and the Affiliated Nanning Infectious Diseases Hospital of Guangxi Medical University, Guangxi Medical University, No. 1, Second Lane, Changgang Road, Nanning, Guangxi 530023, ChinaNo. 4th People's Hospital of Nanning and the Affiliated Nanning Infectious Diseases Hospital of Guangxi Medical University, Guangxi Medical University, No. 1, Second Lane, Changgang Road, Nanning, Guangxi 530023, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi 530021, China; Guangxi Biobank, Life Sciences Institute, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi 530021, China; Correspondence author:Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, No. 22 Shuangyong Road, Nanning, Guangxi 530021, China; Nursing college, Guangxi Medical University, No. 8 Shuangyong Road, Nanning, Guangxi 530021, China; Correspondence author:ABSTRACT: Intestinal Talaromyces marneffei (TM) infection among patients with HIV/AIDS is rare. Herein, we report 31 cases of intestinal TM infection in Guangxi. Most patients exhibited fever, lymphadenectasis in the abdominal cavity, and chronic intestinal symptoms. CD4+ T-cell counts <50 cells/μL were reported in 28 patients. TM was cultured from the blood of 23 patients and from the marrow of 7 patients, whereas TM-like fungal spores in the cytoplasm of tissues with erosion, ulceration, and/or polyps were found in all 31 patients. We suggest that intestinal TM infection should be considered among patients infected with HIV with extremely low CD4+ T-cell counts (<50 cells/μL) who are manifesting fever, chronic gastrointestinal symptoms, and endoscopic evidence of erosion and/or ulceration.http://www.sciencedirect.com/science/article/pii/S1201971222001965TalaromycosisTalaromyces marneffeiHIVAIDSIntestinal |
| spellingShingle | Zhiman Xie Jingzhen Lai Renping Peng Minhong Mou Hao Liang Chuanyi Ning Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern China International Journal of Infectious Diseases Talaromycosis Talaromyces marneffei HIV AIDS Intestinal |
| title | Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern China |
| title_full | Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern China |
| title_fullStr | Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern China |
| title_full_unstemmed | Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern China |
| title_short | Clinical Characteristics of HIV-Associated Talaromyces marneffei Infection of Intestine in Southern China |
| title_sort | clinical characteristics of hiv associated talaromyces marneffei infection of intestine in southern china |
| topic | Talaromycosis Talaromyces marneffei HIV AIDS Intestinal |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222001965 |
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