Cannabis use and mood disorders: a systematic review
BackgroundProblematic cannabis use is highly prevalent among people with mood disorders. This underscores the need to understand the effects of cannabis and cannabinoids in this population, especially considering legalization of recreational cannabis use.ObjectivesWe aimed to (1) systematically eval...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1346207/full |
| _version_ | 1797217017833455616 |
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| author | Maryam Sorkhou Maryam Sorkhou Eliza L. Dent Tony P. George Tony P. George |
| author_facet | Maryam Sorkhou Maryam Sorkhou Eliza L. Dent Tony P. George Tony P. George |
| author_sort | Maryam Sorkhou |
| collection | DOAJ |
| description | BackgroundProblematic cannabis use is highly prevalent among people with mood disorders. This underscores the need to understand the effects of cannabis and cannabinoids in this population, especially considering legalization of recreational cannabis use.ObjectivesWe aimed to (1) systematically evaluate cross-sectional and longitudinal studies investigating the interplay between cannabis use, cannabis use disorder (CUD), and the occurrence of mood disorders and symptoms, with a focus on major depressive disorder (MDD) and bipolar disorder (BD) and; (2) examine the effects of cannabis on the prognosis and treatment outcomes of MDD and BD.MethodsFollowing PRISMA guidelines, we conducted an extensive search for English-language studies investigating the potential impact of cannabis on the development and prognosis of mood disorders published from inception through November 2023, using EMBASE, PsycINFO, PubMed, and MEDLINE databases.ResultsOur literature search identified 3,262 studies, with 78 meeting inclusion criteria. We found that cannabis use is associated with increased depressive and manic symptoms in the general population in addition to an elevated likelihood of developing MDD and BD. Furthermore, we observed that cannabis use is linked to an unfavorable prognosis in both MDD or BD.DiscussionOur findings suggest that cannabis use may negatively influence the development, course, and prognosis of MDD and BD. Future well-designed studies, considering type, amount, and frequency of cannabis use while addressing confounding factors, are imperative for a comprehensive understanding of this relationship.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023481634. |
| first_indexed | 2024-04-24T11:55:10Z |
| format | Article |
| id | doaj.art-24def20bb19e4224bfe77958eeb78e12 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-24T11:55:10Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-24def20bb19e4224bfe77958eeb78e122024-04-09T04:53:02ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-04-011210.3389/fpubh.2024.13462071346207Cannabis use and mood disorders: a systematic reviewMaryam Sorkhou0Maryam Sorkhou1Eliza L. Dent2Tony P. George3Tony P. George4Institute for Mental Health Policy and Research at CAMH, Toronto, ON, CanadaDepartment of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, ON, CanadaDepartment of Psychology, McGill University, Montreal, QC, CanadaInstitute for Mental Health Policy and Research at CAMH, Toronto, ON, CanadaDepartment of Psychiatry, Institute of Medical Sciences, University of Toronto, Toronto, ON, CanadaBackgroundProblematic cannabis use is highly prevalent among people with mood disorders. This underscores the need to understand the effects of cannabis and cannabinoids in this population, especially considering legalization of recreational cannabis use.ObjectivesWe aimed to (1) systematically evaluate cross-sectional and longitudinal studies investigating the interplay between cannabis use, cannabis use disorder (CUD), and the occurrence of mood disorders and symptoms, with a focus on major depressive disorder (MDD) and bipolar disorder (BD) and; (2) examine the effects of cannabis on the prognosis and treatment outcomes of MDD and BD.MethodsFollowing PRISMA guidelines, we conducted an extensive search for English-language studies investigating the potential impact of cannabis on the development and prognosis of mood disorders published from inception through November 2023, using EMBASE, PsycINFO, PubMed, and MEDLINE databases.ResultsOur literature search identified 3,262 studies, with 78 meeting inclusion criteria. We found that cannabis use is associated with increased depressive and manic symptoms in the general population in addition to an elevated likelihood of developing MDD and BD. Furthermore, we observed that cannabis use is linked to an unfavorable prognosis in both MDD or BD.DiscussionOur findings suggest that cannabis use may negatively influence the development, course, and prognosis of MDD and BD. Future well-designed studies, considering type, amount, and frequency of cannabis use while addressing confounding factors, are imperative for a comprehensive understanding of this relationship.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023481634.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1346207/fullcannabismajor depressive disorderbipolar disorderdepressionmaniasuicidality |
| spellingShingle | Maryam Sorkhou Maryam Sorkhou Eliza L. Dent Tony P. George Tony P. George Cannabis use and mood disorders: a systematic review Frontiers in Public Health cannabis major depressive disorder bipolar disorder depression mania suicidality |
| title | Cannabis use and mood disorders: a systematic review |
| title_full | Cannabis use and mood disorders: a systematic review |
| title_fullStr | Cannabis use and mood disorders: a systematic review |
| title_full_unstemmed | Cannabis use and mood disorders: a systematic review |
| title_short | Cannabis use and mood disorders: a systematic review |
| title_sort | cannabis use and mood disorders a systematic review |
| topic | cannabis major depressive disorder bipolar disorder depression mania suicidality |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1346207/full |
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