The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases
In this review, the structure, isoform, and physiological role of the carboxy-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) are summarized. There are three isoforms of CAPON in humans, including long CAPON protein (CAPON-L), short CAPON protein (CAPON-S), and CAPON-S’ protein. CAPON-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15808 |
| _version_ | 1797631771836153856 |
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| author | Wenshuo Xie Nianhong Xing Jicheng Qu Dongwu Liu Qiuxiang Pang |
| author_facet | Wenshuo Xie Nianhong Xing Jicheng Qu Dongwu Liu Qiuxiang Pang |
| author_sort | Wenshuo Xie |
| collection | DOAJ |
| description | In this review, the structure, isoform, and physiological role of the carboxy-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) are summarized. There are three isoforms of CAPON in humans, including long CAPON protein (CAPON-L), short CAPON protein (CAPON-S), and CAPON-S’ protein. CAPON-L includes three functional regions: a C-terminal PDZ-binding motif, carboxypeptidase (CPE)-binding region, and N-terminal phosphotyrosine (PTB) structural domain. Both CAPON-S and CAPON-S’ only contain the C-terminal PDZ-binding motif. The C-terminal PDZ-binding motif of CAPON can bind with neuronal nitric oxide synthase (nNOS) and participates in regulating NO production and neuronal development. An overview is given on the relationship between CAPON and heart diseases, diabetes, psychiatric disorders, and tumors. This review will clarify future research directions on the signal pathways related to CAPON, which will be helpful for studying the regulatory mechanism of CAPON. CAPON may be used as a drug target, which will provide new ideas and solutions for treating human diseases. |
| first_indexed | 2024-03-11T11:28:06Z |
| format | Article |
| id | doaj.art-24df3dd4e6ad454d97d897cb03a9734c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:28:06Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-24df3dd4e6ad454d97d897cb03a9734c2023-11-10T15:05:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124211580810.3390/ijms242115808The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in DiseasesWenshuo Xie0Nianhong Xing1Jicheng Qu2Dongwu Liu3Qiuxiang Pang4Anti-Aging & Regenerative Medicine Research Institution, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, ChinaAnti-Aging & Regenerative Medicine Research Institution, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, ChinaAnti-Aging & Regenerative Medicine Research Institution, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, ChinaAnti-Aging & Regenerative Medicine Research Institution, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, ChinaAnti-Aging & Regenerative Medicine Research Institution, School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255049, ChinaIn this review, the structure, isoform, and physiological role of the carboxy-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) are summarized. There are three isoforms of CAPON in humans, including long CAPON protein (CAPON-L), short CAPON protein (CAPON-S), and CAPON-S’ protein. CAPON-L includes three functional regions: a C-terminal PDZ-binding motif, carboxypeptidase (CPE)-binding region, and N-terminal phosphotyrosine (PTB) structural domain. Both CAPON-S and CAPON-S’ only contain the C-terminal PDZ-binding motif. The C-terminal PDZ-binding motif of CAPON can bind with neuronal nitric oxide synthase (nNOS) and participates in regulating NO production and neuronal development. An overview is given on the relationship between CAPON and heart diseases, diabetes, psychiatric disorders, and tumors. This review will clarify future research directions on the signal pathways related to CAPON, which will be helpful for studying the regulatory mechanism of CAPON. CAPON may be used as a drug target, which will provide new ideas and solutions for treating human diseases.https://www.mdpi.com/1422-0067/24/21/15808neuronal-type nitric oxide synthasenitric oxidecarboxy-terminal PDZ ligand of neuronal nitric oxide synthasephysiological functiondisease |
| spellingShingle | Wenshuo Xie Nianhong Xing Jicheng Qu Dongwu Liu Qiuxiang Pang The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases International Journal of Molecular Sciences neuronal-type nitric oxide synthase nitric oxide carboxy-terminal PDZ ligand of neuronal nitric oxide synthase physiological function disease |
| title | The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases |
| title_full | The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases |
| title_fullStr | The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases |
| title_full_unstemmed | The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases |
| title_short | The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases |
| title_sort | physiological function of nnos associated capon proteins and the roles of capon in diseases |
| topic | neuronal-type nitric oxide synthase nitric oxide carboxy-terminal PDZ ligand of neuronal nitric oxide synthase physiological function disease |
| url | https://www.mdpi.com/1422-0067/24/21/15808 |
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