Biphasic effects of statins on neuron cell functions under oxygen–glucose deprivation and normal culturing conditions via different mechanisms

Biphasic effects of statins on neuron cell functions under oxygen–glucose deprivation and normal culturing conditions via different mechanisms

Abstract While there is a growing interest in the use of statins, HMG‐CoA reductase inhibitors, to treat neurodegenerative diseases, statins are associated with conflicting effects within the central nervous system (CNS) without clear evidence of the underlying mechanisms. This study systematically...

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Bibliographic Details
Main Authors: Hui Wang, Yun Chen, Ping Li, Yan Chen, Danfang Yu, Qian Tan, Xiaoli Liu, Zhenli Guo
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Pharmacology Research & Perspectives
Subjects:
neuron cells
OGD
oxidative stress
prenylation
statins
Online Access:https://doi.org/10.1002/prp2.1001

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