Acral Melanoma Is Infiltrated with cDC1s and Functional Exhausted CD8 T Cells Similar to the Cutaneous Melanoma of Sun-Exposed Skin

Acral Melanoma Is Infiltrated with cDC1s and Functional Exhausted CD8 T Cells Similar to the Cutaneous Melanoma of Sun-Exposed Skin

Acral melanoma (AM) is the most common melanoma in non-Caucasian populations, yet it remains largely understudied. As AM lacks the UV-radiation mutational signatures that characterize other cutaneous melanomas, it is considered devoid of immunogenicity and is rarely included in clinical trials asses...

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Bibliographic Details
Main Authors: Saraí G. De Leon-Rodríguez, Cristina Aguilar-Flores, Julián A. Gajón, Alejandra Mantilla, Raquel Gerson-Cwilich, José Fabián Martínez-Herrera, Benigno E. Rodríguez-Soto, Claudia T. Gutiérrez-Quiroz, Vadim Pérez-Koldenkova, Samira Muñoz-Cruz, Laura C. Bonifaz, Ezequiel M. Fuentes-Pananá
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
acral
CD8
cDC1s
PD-1
PD-L1
Online Access:https://www.mdpi.com/1422-0067/24/5/4786

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https://www.mdpi.com/1422-0067/24/5/4786

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