Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2
This paper describes an eco-friendly and efficient direct amidation of benzylamine and phenylacetic acid derivatives in the presence of 10 mol% NiCl2 as catalyst without any drying agent. For the different phenylacetic acid and benzylamine derivatives, the direct catalysed amidation gave moderate-to...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2018-01-01
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| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171870 |
| _version_ | 1831799459039674368 |
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| author | Lidan Cheng Xiaoping Ge Longjiang Huang |
| author_facet | Lidan Cheng Xiaoping Ge Longjiang Huang |
| author_sort | Lidan Cheng |
| collection | DOAJ |
| description | This paper describes an eco-friendly and efficient direct amidation of benzylamine and phenylacetic acid derivatives in the presence of 10 mol% NiCl2 as catalyst without any drying agent. For the different phenylacetic acid and benzylamine derivatives, the direct catalysed amidation gave moderate-to-excellent yields in toluene. The steric and electronic effects of substituent groups on the phenyl ring of acid were crucial to the yields of the direct amidation. The catalyst NiCl2 can be recycled three times without loss of activity. |
| first_indexed | 2024-12-22T17:46:38Z |
| format | Article |
| id | doaj.art-24e7cd143114449bbcbf104222cece9d |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-22T17:46:38Z |
| publishDate | 2018-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-24e7cd143114449bbcbf104222cece9d2022-12-21T18:18:17ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015210.1098/rsos.171870171870Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2Lidan ChengXiaoping GeLongjiang HuangThis paper describes an eco-friendly and efficient direct amidation of benzylamine and phenylacetic acid derivatives in the presence of 10 mol% NiCl2 as catalyst without any drying agent. For the different phenylacetic acid and benzylamine derivatives, the direct catalysed amidation gave moderate-to-excellent yields in toluene. The steric and electronic effects of substituent groups on the phenyl ring of acid were crucial to the yields of the direct amidation. The catalyst NiCl2 can be recycled three times without loss of activity.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171870direct amidationnickel dichloridephenylacetic acid derivativesbenzylamine derivatives |
| spellingShingle | Lidan Cheng Xiaoping Ge Longjiang Huang Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2 Royal Society Open Science direct amidation nickel dichloride phenylacetic acid derivatives benzylamine derivatives |
| title | Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2 |
| title_full | Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2 |
| title_fullStr | Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2 |
| title_full_unstemmed | Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2 |
| title_short | Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl2 |
| title_sort | direct amidation of non activated phenylacetic acid and benzylamine derivatives catalysed by nicl2 |
| topic | direct amidation nickel dichloride phenylacetic acid derivatives benzylamine derivatives |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171870 |
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