Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study
Although cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Here, we investigated with three different neuroimaging modalities (magnetoencephalography (MEG...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00725/full |
| _version_ | 1818243952787062784 |
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| author | CHRISTOS ePAPADELIS CHRISTOS ePAPADELIS Banu eAhtam Banu eAhtam Maria eNazarova Maria eNazarova Donna eNimec Brian eSnyder Patricia Ellen eGrant Patricia Ellen eGrant Patricia Ellen eGrant Yoshio eOkada Yoshio eOkada |
| author_facet | CHRISTOS ePAPADELIS CHRISTOS ePAPADELIS Banu eAhtam Banu eAhtam Maria eNazarova Maria eNazarova Donna eNimec Brian eSnyder Patricia Ellen eGrant Patricia Ellen eGrant Patricia Ellen eGrant Yoshio eOkada Yoshio eOkada |
| author_sort | CHRISTOS ePAPADELIS |
| collection | DOAJ |
| description | Although cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Here, we investigated with three different neuroimaging modalities (magnetoencephalography (MEG), diffusion tension imaging (DTI), and resting state fMRI) whether spastic CP is associated with functional and anatomical abnormalities in the sensorimotor network. Ten children participated in the study: four with diplegic CP (DCP), three with hemiplegic CP (HCP), and three typically-developing (TD) children. Somatosensory evoked fields (SEFs) were recorded in response to pneumatic stimuli applied to digits D1, D3, and D5 of both hands. Several parameters of water diffusion were calculated from DTI between the thalamus and the precentral and postcentral gyri in both hemispheres. The sensorimotor resting state networks (RSNs) were examined by using an independent component analysis method. Tactile stimulation of the fingers elicited the first prominent cortical response at ~50 ms, in all except one child, localized over the primary somatosensory cortex (S1). In five CP children, abnormal somatotopic organization was observed in the affected (or more affected) hemisphere. Euclidean distances were markedly different between the two hemispheres in the HCP children, and between DCP and TD children for both hemispheres. DTI analysis revealed decreased fractional anisotropy and increased apparent diffusion coefficient for the thalamocortical pathways in the more affected compared to less affected hemisphere in CP children. Rs-fMRI results indicated absent and/or abnormal sensorimotor RSNs for children with HCP and DCP consistent with the severity and location of their lesions. Our findings suggest an abnormal somatosensory processing mechanism in the sensorimotor network of children with CP possibly as a result of diminished thalamocortical projections. |
| first_indexed | 2024-12-12T14:09:18Z |
| format | Article |
| id | doaj.art-24e85b907e694334a0eea8ce60cfcd7a |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-12T14:09:18Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-24e85b907e694334a0eea8ce60cfcd7a2022-12-22T00:22:07ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-09-01810.3389/fnhum.2014.00725100632Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging studyCHRISTOS ePAPADELIS0CHRISTOS ePAPADELIS1Banu eAhtam2Banu eAhtam3Maria eNazarova4Maria eNazarova5Donna eNimec6Brian eSnyder7Patricia Ellen eGrant8Patricia Ellen eGrant9Patricia Ellen eGrant10Yoshio eOkada11Yoshio eOkada12Boston Children's Hospital, Harvard Medical SchoolBoston Children’s Hospital, Harvard Medical SchoolBoston Children's Hospital, Harvard Medical SchoolBoston Children’s Hospital, Harvard Medical SchoolResearch Center of NeurologyHigher School of EconomicsBoston Children's Hospital, Harvard Medical SchoolBoston Children's Hospital, Harvard Medical SchoolBoston Children's Hospital, Harvard Medical SchoolBoston Children’s Hospital, Harvard Medical SchoolBoston Children's Hospital, Harvard Medical SchoolBoston Children's Hospital, Harvard Medical SchoolBoston Children’s Hospital, Harvard Medical SchoolAlthough cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about the functional and structural changes of this disorder in the developing brain. Here, we investigated with three different neuroimaging modalities (magnetoencephalography (MEG), diffusion tension imaging (DTI), and resting state fMRI) whether spastic CP is associated with functional and anatomical abnormalities in the sensorimotor network. Ten children participated in the study: four with diplegic CP (DCP), three with hemiplegic CP (HCP), and three typically-developing (TD) children. Somatosensory evoked fields (SEFs) were recorded in response to pneumatic stimuli applied to digits D1, D3, and D5 of both hands. Several parameters of water diffusion were calculated from DTI between the thalamus and the precentral and postcentral gyri in both hemispheres. The sensorimotor resting state networks (RSNs) were examined by using an independent component analysis method. Tactile stimulation of the fingers elicited the first prominent cortical response at ~50 ms, in all except one child, localized over the primary somatosensory cortex (S1). In five CP children, abnormal somatotopic organization was observed in the affected (or more affected) hemisphere. Euclidean distances were markedly different between the two hemispheres in the HCP children, and between DCP and TD children for both hemispheres. DTI analysis revealed decreased fractional anisotropy and increased apparent diffusion coefficient for the thalamocortical pathways in the more affected compared to less affected hemisphere in CP children. Rs-fMRI results indicated absent and/or abnormal sensorimotor RSNs for children with HCP and DCP consistent with the severity and location of their lesions. Our findings suggest an abnormal somatosensory processing mechanism in the sensorimotor network of children with CP possibly as a result of diminished thalamocortical projections.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00725/fullCerebral PalsySomatosensory CortexMultimodal ImagingBrain reorganisationthalamocortical projectionssensorimotor network |
| spellingShingle | CHRISTOS ePAPADELIS CHRISTOS ePAPADELIS Banu eAhtam Banu eAhtam Maria eNazarova Maria eNazarova Donna eNimec Brian eSnyder Patricia Ellen eGrant Patricia Ellen eGrant Patricia Ellen eGrant Yoshio eOkada Yoshio eOkada Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study Frontiers in Human Neuroscience Cerebral Palsy Somatosensory Cortex Multimodal Imaging Brain reorganisation thalamocortical projections sensorimotor network |
| title | Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study |
| title_full | Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study |
| title_fullStr | Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study |
| title_full_unstemmed | Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study |
| title_short | Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study |
| title_sort | cortical somatosensory reorganization in children with spastic cerebral palsy a multimodal neuroimaging study |
| topic | Cerebral Palsy Somatosensory Cortex Multimodal Imaging Brain reorganisation thalamocortical projections sensorimotor network |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00725/full |
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