Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men
Background Smoking is an overwhelming, but preventable, risk factor for cardiovascular diseases (CVD), although smoking prevalence remains high in developed and developing countries in East Asia. Methods and Results In a population‐based sample of 1019 Japanese men aged 40 to 79 years, without CVD,...
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| Format: | Article |
| Language: | English |
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Wiley
2016-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1161/JAHA.116.003738 |
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| author | Takashi Hisamatsu Katsuyuki Miura Hisatomi Arima Aya Kadota Sayaka Kadowaki Sayuki Torii Sentaro Suzuki Naoko Miyagawa Atsushi Sato Masahiro Yamazoe Akira Fujiyoshi Takayoshi Ohkubo Takashi Yamamoto Kiyoshi Murata Robert D. Abbott Akira Sekikawa Minoru Horie Hirotsugu Ueshima the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group |
| author_facet | Takashi Hisamatsu Katsuyuki Miura Hisatomi Arima Aya Kadota Sayaka Kadowaki Sayuki Torii Sentaro Suzuki Naoko Miyagawa Atsushi Sato Masahiro Yamazoe Akira Fujiyoshi Takayoshi Ohkubo Takashi Yamamoto Kiyoshi Murata Robert D. Abbott Akira Sekikawa Minoru Horie Hirotsugu Ueshima the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group |
| author_sort | Takashi Hisamatsu |
| collection | DOAJ |
| description | Background Smoking is an overwhelming, but preventable, risk factor for cardiovascular diseases (CVD), although smoking prevalence remains high in developed and developing countries in East Asia. Methods and Results In a population‐based sample of 1019 Japanese men aged 40 to 79 years, without CVD, we examined cross‐sectional associations of smoking status, cumulative pack‐years, daily consumption, and time since cessation, with subclinical atherosclerosis at 4 anatomically distinct vascular beds, including coronary artery calcification, carotid intima‐media thickness (CIMT) and plaque, aortic artery calcification (AoAC), and ankle‐brachial index. Current, former, and never smoking were present in 32.3%, 50.0%, and 17.7%, respectively. Compared to never smokers, current smokers had significantly higher risks of subclinical atherosclerosis in all 4 circulations (eg, odds ratios for coronary artery calcification >0, 1.79 [95% CIs, 1.16–2.79]; CIMT >1.0 mm, 1.88 [1.02–3.47]; AoAC >0, 4.29 [2.30–7.97]; and ankle‐brachial index <1.1, 1.78 [1.16–2.74]) and former smokers did in carotid and aortic circulations (CIMT >1.0 mm, 1.94 [1.13–3.34]; and AoAC >0, 2.55 [1.45–4.49]). Dose–response relationships of pack‐years and daily consumption, particularly with CIMT, carotid plaque, AoAC, and ankle‐brachial index, were observed among both current and former smokers, and even a small amount of pack‐years or daily consumption among current smokers was associated with coronary artery calcification and AoAC, whereas time since cessation among former smokers was linearly associated with lower burdens of all atherosclerotic indices. Conclusions Cigarette smoking was strongly associated with subclinical atherosclerosis in multiple vascular beds in Japanese men, and these associations attenuated with time since cessation. |
| first_indexed | 2024-12-21T21:14:32Z |
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| id | doaj.art-24ea118ca36a4b3089374f7628c9f19e |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-21T21:14:32Z |
| publishDate | 2016-09-01 |
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| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-24ea118ca36a4b3089374f7628c9f19e2022-12-21T18:50:03ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-09-0159n/an/a10.1161/JAHA.116.003738Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese MenTakashi Hisamatsu0Katsuyuki Miura1Hisatomi Arima2Aya Kadota3Sayaka Kadowaki4Sayuki Torii5Sentaro Suzuki6Naoko Miyagawa7Atsushi Sato8Masahiro Yamazoe9Akira Fujiyoshi10Takayoshi Ohkubo11Takashi Yamamoto12Kiyoshi Murata13Robert D. Abbott14Akira Sekikawa15Minoru Horie16Hirotsugu Ueshima17the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research GroupDepartment of Environmental Medicine and Public Health Faculty of Medicine Shimane University Izumo JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanDepartment of Hygiene and Public Health Teikyo University School of Medicine Tokyo JapanDepartment of Cardiovascular and Respiratory Medicine Shiga University of Medical Science Otsu JapanDepartment of Radiology Shiga University of Medical Science Otsu JapanCenter for Epidemiologic Research in Asia Shiga University of Medical Science Otsu JapanDepartment of Epidemiology Graduate School of Public Health University of Pittsburgh PADepartment of Cardiovascular and Respiratory Medicine Shiga University of Medical Science Otsu JapanDepartment of Public Health Shiga University of Medical Science Otsu JapanBackground Smoking is an overwhelming, but preventable, risk factor for cardiovascular diseases (CVD), although smoking prevalence remains high in developed and developing countries in East Asia. Methods and Results In a population‐based sample of 1019 Japanese men aged 40 to 79 years, without CVD, we examined cross‐sectional associations of smoking status, cumulative pack‐years, daily consumption, and time since cessation, with subclinical atherosclerosis at 4 anatomically distinct vascular beds, including coronary artery calcification, carotid intima‐media thickness (CIMT) and plaque, aortic artery calcification (AoAC), and ankle‐brachial index. Current, former, and never smoking were present in 32.3%, 50.0%, and 17.7%, respectively. Compared to never smokers, current smokers had significantly higher risks of subclinical atherosclerosis in all 4 circulations (eg, odds ratios for coronary artery calcification >0, 1.79 [95% CIs, 1.16–2.79]; CIMT >1.0 mm, 1.88 [1.02–3.47]; AoAC >0, 4.29 [2.30–7.97]; and ankle‐brachial index <1.1, 1.78 [1.16–2.74]) and former smokers did in carotid and aortic circulations (CIMT >1.0 mm, 1.94 [1.13–3.34]; and AoAC >0, 2.55 [1.45–4.49]). Dose–response relationships of pack‐years and daily consumption, particularly with CIMT, carotid plaque, AoAC, and ankle‐brachial index, were observed among both current and former smokers, and even a small amount of pack‐years or daily consumption among current smokers was associated with coronary artery calcification and AoAC, whereas time since cessation among former smokers was linearly associated with lower burdens of all atherosclerotic indices. Conclusions Cigarette smoking was strongly associated with subclinical atherosclerosis in multiple vascular beds in Japanese men, and these associations attenuated with time since cessation.https://doi.org/10.1161/JAHA.116.003738atherosclerosiscoronary artery calcificationcumulative pack‐years exposurepreventionsmokingsmoking cessation |
| spellingShingle | Takashi Hisamatsu Katsuyuki Miura Hisatomi Arima Aya Kadota Sayaka Kadowaki Sayuki Torii Sentaro Suzuki Naoko Miyagawa Atsushi Sato Masahiro Yamazoe Akira Fujiyoshi Takayoshi Ohkubo Takashi Yamamoto Kiyoshi Murata Robert D. Abbott Akira Sekikawa Minoru Horie Hirotsugu Ueshima the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atherosclerosis coronary artery calcification cumulative pack‐years exposure prevention smoking smoking cessation |
| title | Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men |
| title_full | Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men |
| title_fullStr | Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men |
| title_full_unstemmed | Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men |
| title_short | Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men |
| title_sort | smoking smoking cessation and measures of subclinical atherosclerosis in multiple vascular beds in japanese men |
| topic | atherosclerosis coronary artery calcification cumulative pack‐years exposure prevention smoking smoking cessation |
| url | https://doi.org/10.1161/JAHA.116.003738 |
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