A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.
A complete understanding of negative selection has been elusive due to the rapid apoptosis and clearance of thymocytes in vivo. We report a TCR transgenic model in which expression of the TCR during differentiation occurs only after V(D)J-like recombination. TCR expression from this transgene closel...
Main Authors: | Damian Kovalovsky, Mark Pezzano, Benjamin D Ortiz, Derek B Sant'Angelo |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2800196?pdf=render |
Similar Items
-
BIM leadership theory for organisational BIM transformation
by: Oluseye Olugboyega
Published: (2022-10-01) -
Dall’OpenBIM allo ScanToBIM
by: Renzo Carlucci
Published: (2022-12-01) -
Dall’OpenBIM allo ScanToBIM
by: Renzo Carlucci
Published: (2022-12-01) -
Dall’OpenBIM allo ScanToBIM
by: Renzo Carlucci
Published: (2022-12-01) -
Using BIM to manage and reduce delay in construction projects /
by: Shahin Nazem, 1971-, et al.
Published: (2015)