Silk nanoparticles—an emerging anticancer nanomedicine
Silk is a sustainable and ecologically friendly biopolymer with a robust clinical track record in humans for load bearing applications, in part due to its excellent mechanical properties and biocompatibility. Our ability to take bottom-up and top-down approaches for the generation of silk (inspired)...
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| Format: | Article |
| Language: | English |
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AIMS Press
2017-03-01
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| Series: | AIMS Bioengineering |
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| Online Access: | http://www.aimspress.com/Bioengineering/article/1335/fulltext.html |
| _version_ | 1819168779690573824 |
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| author | F. Philipp Seib |
| author_facet | F. Philipp Seib |
| author_sort | F. Philipp Seib |
| collection | DOAJ |
| description | Silk is a sustainable and ecologically friendly biopolymer with a robust clinical track record in humans for load bearing applications, in part due to its excellent mechanical properties and biocompatibility. Our ability to take bottom-up and top-down approaches for the generation of silk (inspired) biopolymers has been critical in supporting the evolution of silk materials and formats, including silk nanoparticles for drug delivery. Silk nanoparticles are emerging as interesting contenders for drug delivery and are well placed to advance the nanomedicine field. This review covers the use of <em>Bombyx mori</em> and recombinant silks as an anticancer nanomedicine, highlighting the emerging trends and developments as well as critically assessing the current opportunities and challenges by providing a context specific assessment of this multidisciplinary field. |
| first_indexed | 2024-12-22T19:09:02Z |
| format | Article |
| id | doaj.art-24eb5e0cba2c4945b0889e85dc94ea0f |
| institution | Directory Open Access Journal |
| issn | 2375-1495 |
| language | English |
| last_indexed | 2024-12-22T19:09:02Z |
| publishDate | 2017-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Bioengineering |
| spelling | doaj.art-24eb5e0cba2c4945b0889e85dc94ea0f2022-12-21T18:15:44ZengAIMS PressAIMS Bioengineering2375-14952017-03-014223925810.3934/bioeng.2017.2.239bioeng-04-00239Silk nanoparticles—an emerging anticancer nanomedicineF. Philipp SeibSilk is a sustainable and ecologically friendly biopolymer with a robust clinical track record in humans for load bearing applications, in part due to its excellent mechanical properties and biocompatibility. Our ability to take bottom-up and top-down approaches for the generation of silk (inspired) biopolymers has been critical in supporting the evolution of silk materials and formats, including silk nanoparticles for drug delivery. Silk nanoparticles are emerging as interesting contenders for drug delivery and are well placed to advance the nanomedicine field. This review covers the use of <em>Bombyx mori</em> and recombinant silks as an anticancer nanomedicine, highlighting the emerging trends and developments as well as critically assessing the current opportunities and challenges by providing a context specific assessment of this multidisciplinary field.http://www.aimspress.com/Bioengineering/article/1335/fulltext.htmlsilkfibroinnanomedicinenanoparticledrug deliveryBombyx moritargetingEPRendocytosis |
| spellingShingle | F. Philipp Seib Silk nanoparticles—an emerging anticancer nanomedicine AIMS Bioengineering silk fibroin nanomedicine nanoparticle drug delivery Bombyx mori targeting EPR endocytosis |
| title | Silk nanoparticles—an emerging anticancer nanomedicine |
| title_full | Silk nanoparticles—an emerging anticancer nanomedicine |
| title_fullStr | Silk nanoparticles—an emerging anticancer nanomedicine |
| title_full_unstemmed | Silk nanoparticles—an emerging anticancer nanomedicine |
| title_short | Silk nanoparticles—an emerging anticancer nanomedicine |
| title_sort | silk nanoparticles an emerging anticancer nanomedicine |
| topic | silk fibroin nanomedicine nanoparticle drug delivery Bombyx mori targeting EPR endocytosis |
| url | http://www.aimspress.com/Bioengineering/article/1335/fulltext.html |
| work_keys_str_mv | AT fphilippseib silknanoparticlesanemerginganticancernanomedicine |