Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1−/− Mouse

Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1−/− Mouse

Insulin-like growth factor 1 (IGF-1) is a powerful regulator of synaptic activity and a deficit in this protein has a profound impact on neurotransmission, mostly on excitatory synapses in both the developing and mature auditory system. Adult Igf1−/− mice are animal models for the study of human syn...

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Bibliographic Details
Main Authors: Veronica Fuentes-Santamaría, Juan C. Alvarado, Lourdes Rodríguez-de la Rosa, José M. Juiz, Isabel Varela-Nieto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hearing loss
cochlear nucleus
IGF-1
glutamate receptors
astrocytes
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00067/full

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