Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery
Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/13/2267 |
| _version_ | 1827619345560240128 |
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| author | Yu Wu Miora Rakotoarisoa Borislav Angelov Yuru Deng Angelina Angelova |
| author_facet | Yu Wu Miora Rakotoarisoa Borislav Angelov Yuru Deng Angelina Angelova |
| author_sort | Yu Wu |
| collection | DOAJ |
| description | Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, and RNAi sequences) in clinical developments for neuronal regeneration should benefit from the recent strategies for enhancement of their bioavailability. We highlight the advances in the development of nanoscale materials for drug delivery in neurodegenerative disorders. The emphasis is placed on nanoformulations for the delivery of brain-derived neurotrophic factor (BDNF) using different types of lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) and polymer-based scaffolds, nanofibers and hydrogels. Self-assembled soft-matter nanoscale materials show favorable neuroprotective characteristics, safety, and efficacy profiles in drug delivery to the central and peripheral nervous systems. The advances summarized here indicate that neuroprotective biomolecule-loaded nanoparticles and injectable hydrogels can improve neuronal survival and reduce tissue injury. Certain recently reported neuronal dysfunctions in long-COVID-19 survivors represent early manifestations of neurodegenerative pathologies. Therefore, BDNF delivery systems may also help in prospective studies on recovery from long-term COVID-19 neurological complications and be considered as promising systems for personalized treatment of neuronal dysfunctions and prevention or retarding of neurodegenerative disorders. |
| first_indexed | 2024-03-09T10:26:16Z |
| format | Article |
| id | doaj.art-24ec692a40134105bb0e0e3bfb15691c |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T10:26:16Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-24ec692a40134105bb0e0e3bfb15691c2023-12-01T21:37:42ZengMDPI AGNanomaterials2079-49912022-06-011213226710.3390/nano12132267Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic DeliveryYu Wu0Miora Rakotoarisoa1Borislav Angelov2Yuru Deng3Angelina Angelova4CNRS, Institut Galien Paris-Saclay, Université Paris-Saclay, F-92290 Châtenay-Malabry, FranceCNRS, Institut Galien Paris-Saclay, Université Paris-Saclay, F-92290 Châtenay-Malabry, FranceInstitute of Physics, ELI Beamlines, Academy of Sciences of the Czech Republic, Na Slovance 2, CZ-18221 Prague, Czech RepublicWenzhou Institute, University of Chinese Academy of Sciences, No. 1, Jinlian Road, Longwan District, Wenzhou 325001, ChinaCNRS, Institut Galien Paris-Saclay, Université Paris-Saclay, F-92290 Châtenay-Malabry, FranceEnabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, and RNAi sequences) in clinical developments for neuronal regeneration should benefit from the recent strategies for enhancement of their bioavailability. We highlight the advances in the development of nanoscale materials for drug delivery in neurodegenerative disorders. The emphasis is placed on nanoformulations for the delivery of brain-derived neurotrophic factor (BDNF) using different types of lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) and polymer-based scaffolds, nanofibers and hydrogels. Self-assembled soft-matter nanoscale materials show favorable neuroprotective characteristics, safety, and efficacy profiles in drug delivery to the central and peripheral nervous systems. The advances summarized here indicate that neuroprotective biomolecule-loaded nanoparticles and injectable hydrogels can improve neuronal survival and reduce tissue injury. Certain recently reported neuronal dysfunctions in long-COVID-19 survivors represent early manifestations of neurodegenerative pathologies. Therefore, BDNF delivery systems may also help in prospective studies on recovery from long-term COVID-19 neurological complications and be considered as promising systems for personalized treatment of neuronal dysfunctions and prevention or retarding of neurodegenerative disorders.https://www.mdpi.com/2079-4991/12/13/2267neuroprotective assembliesbrain-derived neurotrophic factor (BDNF)nanomedicine for growth factor deliverylipid nanoparticlesnanocarriersnanofibers |
| spellingShingle | Yu Wu Miora Rakotoarisoa Borislav Angelov Yuru Deng Angelina Angelova Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery Nanomaterials neuroprotective assemblies brain-derived neurotrophic factor (BDNF) nanomedicine for growth factor delivery lipid nanoparticles nanocarriers nanofibers |
| title | Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery |
| title_full | Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery |
| title_fullStr | Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery |
| title_full_unstemmed | Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery |
| title_short | Self-Assembled Nanoscale Materials for<italic/> Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery |
| title_sort | self assembled nanoscale materials for italic neuronal regeneration a focus on bdnf protein and nucleic acid biotherapeutic delivery |
| topic | neuroprotective assemblies brain-derived neurotrophic factor (BDNF) nanomedicine for growth factor delivery lipid nanoparticles nanocarriers nanofibers |
| url | https://www.mdpi.com/2079-4991/12/13/2267 |
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