Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their Families
Background: Generalized vitiligo is an acquired disorder in which depigmented macules result from the autoimmune loss of melanocytes from the involved regions of skin. Generalized vitiligo is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases (Hashimoto�...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015305591 |
| _version_ | 1811343339270701056 |
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| author | Tomohiko Narita Naoki Oiso Kazuyoshi Fukai Kenji Kabashima Akira Kawada Tamio Suzuki |
| author_facet | Tomohiko Narita Naoki Oiso Kazuyoshi Fukai Kenji Kabashima Akira Kawada Tamio Suzuki |
| author_sort | Tomohiko Narita |
| collection | DOAJ |
| description | Background: Generalized vitiligo is an acquired disorder in which depigmented macules result from the autoimmune loss of melanocytes from the involved regions of skin. Generalized vitiligo is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases (Hashimoto's thyroiditis and Graves' disease), rheumatoid arthritis, adult-onset type 1 diabetes mellitus, psoriasis, pernicious anemia, systemic lupus erythematosus, and Addison's disease.
Methods: One hundred and thirty-three Japanese patients with generalized vitiligo were enrolled in this study to investigate the occurrence of autoimmune diseases in Japanese patients with generalized vitiligo and their families.
Results: Twenty-seven of the patients with generalized vitiligo (20.3%) had autoimmune diseases, particularly autoimmune thyroid disease (sixteen patients, 12%) and alopecia areata (seven patients, 5.3%). Thirty-five patients (26.3%) had a family history of generalized vitiligo and/or other autoimmune diseases. Familial generalized vitiligo was present in fifteen (11.3%), including four families with members affected by autoimmune disorders. Twenty (15.0%) had one or more family members with only autoimmune disorders.
Conclusions: Among Japanese vitiligo patients, there is a subgroup with strong evidence of genetically determined susceptibility to not only vitiligo, but also to autoimmune thyroid disease and other autoimmune disorders. |
| first_indexed | 2024-04-13T19:27:34Z |
| format | Article |
| id | doaj.art-24ecdcc52ef6441697dba546291f80f3 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-13T19:27:34Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-24ecdcc52ef6441697dba546291f80f32022-12-22T02:33:16ZengElsevierAllergology International1323-89302011-01-0160450550810.2332/allergolint.11-OA-0303Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their FamiliesTomohiko Narita0Naoki Oiso1Kazuyoshi Fukai2Kenji Kabashima3Akira Kawada4Tamio Suzuki5Department of Dermatology, Kinki University Faculty of Medicine, Yamagata, JapanDepartment of Dermatology, Kinki University Faculty of Medicine, Yamagata, JapanDepartment of Dermatology, Osaka City University Graduate School of Medicine Osaka, JapanDepartment of Dermatology, University of Environmental and Occupational Health, Fukuoka, JapanDepartment of Dermatology, Kinki University Faculty of Medicine, Yamagata, JapanDepartment of Dermatology, Yamagata University School of Medicine, Yamagata, Japan.Background: Generalized vitiligo is an acquired disorder in which depigmented macules result from the autoimmune loss of melanocytes from the involved regions of skin. Generalized vitiligo is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases (Hashimoto's thyroiditis and Graves' disease), rheumatoid arthritis, adult-onset type 1 diabetes mellitus, psoriasis, pernicious anemia, systemic lupus erythematosus, and Addison's disease. Methods: One hundred and thirty-three Japanese patients with generalized vitiligo were enrolled in this study to investigate the occurrence of autoimmune diseases in Japanese patients with generalized vitiligo and their families. Results: Twenty-seven of the patients with generalized vitiligo (20.3%) had autoimmune diseases, particularly autoimmune thyroid disease (sixteen patients, 12%) and alopecia areata (seven patients, 5.3%). Thirty-five patients (26.3%) had a family history of generalized vitiligo and/or other autoimmune diseases. Familial generalized vitiligo was present in fifteen (11.3%), including four families with members affected by autoimmune disorders. Twenty (15.0%) had one or more family members with only autoimmune disorders. Conclusions: Among Japanese vitiligo patients, there is a subgroup with strong evidence of genetically determined susceptibility to not only vitiligo, but also to autoimmune thyroid disease and other autoimmune disorders.http://www.sciencedirect.com/science/article/pii/S1323893015305591alopecia areataautoimmune diseaseautoimmune thyroid diseasegeneralized vitiligorheumatoid arthritis |
| spellingShingle | Tomohiko Narita Naoki Oiso Kazuyoshi Fukai Kenji Kabashima Akira Kawada Tamio Suzuki Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their Families Allergology International alopecia areata autoimmune disease autoimmune thyroid disease generalized vitiligo rheumatoid arthritis |
| title | Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their Families |
| title_full | Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their Families |
| title_fullStr | Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their Families |
| title_full_unstemmed | Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their Families |
| title_short | Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients Their Families |
| title_sort | generalized vitiligo associated autoimmune diseases in japanese patients their families |
| topic | alopecia areata autoimmune disease autoimmune thyroid disease generalized vitiligo rheumatoid arthritis |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015305591 |
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