Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/3/802 |
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| author | Paolo Severino Andrea D’Amato Lucrezia Netti Mariateresa Pucci Marialaura De Marchis Raffaele Palmirotta Maurizio Volterrani Massimo Mancone Francesco Fedele |
| author_facet | Paolo Severino Andrea D’Amato Lucrezia Netti Mariateresa Pucci Marialaura De Marchis Raffaele Palmirotta Maurizio Volterrani Massimo Mancone Francesco Fedele |
| author_sort | Paolo Severino |
| collection | DOAJ |
| description | Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD. |
| first_indexed | 2024-04-12T03:05:54Z |
| format | Article |
| id | doaj.art-24ef4ad6a625473e8c44919290f0d1b5 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T03:05:54Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-24ef4ad6a625473e8c44919290f0d1b52022-12-22T03:50:30ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-03-0119380210.3390/ijms19030802ijms19030802Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion ChannelsPaolo Severino0Andrea D’Amato1Lucrezia Netti2Mariateresa Pucci3Marialaura De Marchis4Raffaele Palmirotta5Maurizio Volterrani6Massimo Mancone7Francesco Fedele8Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Biomedical Sciences and Clinical Oncology Oncogenomic Research Center, ‘Aldo Moro’ University of Bari, 70124 Bari, ItalyDepartment of Cardiac Rehabilitation, IRCCS San Raffaele, 00163 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, ItalyDiabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD.http://www.mdpi.com/1422-0067/19/3/802ion channelscoronary blood flowdiabetes mellitusischemic heart disease |
| spellingShingle | Paolo Severino Andrea D’Amato Lucrezia Netti Mariateresa Pucci Marialaura De Marchis Raffaele Palmirotta Maurizio Volterrani Massimo Mancone Francesco Fedele Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels International Journal of Molecular Sciences ion channels coronary blood flow diabetes mellitus ischemic heart disease |
| title | Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels |
| title_full | Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels |
| title_fullStr | Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels |
| title_full_unstemmed | Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels |
| title_short | Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels |
| title_sort | diabetes mellitus and ischemic heart disease the role of ion channels |
| topic | ion channels coronary blood flow diabetes mellitus ischemic heart disease |
| url | http://www.mdpi.com/1422-0067/19/3/802 |
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