Diffusion Perfusion MRI in Idiopathic Pseudotumor Cerebri
OBJECTIVE: Pseudotumor cerebri (PC) or idiopathic benign intracranial hypertension is characterized by abnormal elevation of intracranial pressure with a normal composition of the cerebrospinal fluid (CSF) and absence of hydrocephaly or any intracranial mass lesion. Papilledema is the major clin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2006-02-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://www.journalagent.com/tjn/pdfs/TJN_12_1_25_29.pdf |
| Summary: | OBJECTIVE: Pseudotumor cerebri (PC) or idiopathic benign
intracranial hypertension is characterized by abnormal elevation of
intracranial pressure with a normal composition of the cerebrospinal
fluid (CSF) and absence of hydrocephaly or any intracranial mass lesion.
Papilledema is the major clinical finding whereas neuroradiological
imaging findings are almost always normal
METHODS: In this preliminary study, we aimed to find out whether
diffusion and perfusion magnetic resonance (MR) imaging in PC patients
might be beneficial in the diagnosis.
RESULTS: We prospectively evaluated diffusion and perfusion MR
findings of 10 PC patients and 10 normal control group. On physical
examination, all PC patients had characteristic papilledema, varying
degrees of headache, blurred vision and tinnitus. Cerebrospinal fluid
(CSF) pressure was higher than 250mm H2O in all patients. MR imaging
was performed with a 1.5 tesla equipment and postprocess analyses
were done on an independent workstation.
There were no diffusion abnormalities in CP patients or differences
when compared to normal group. Perfusion abnormal ities were
detected in seven patients.
CONCLUSION: Pseudotumor cerebri is a clinical syndrome which requires prompt diagnosis and thorough evaluation. Treatment is crucial for
preventing visual loss and improving associated symptoms. Since
majority of the patients lack specific neuroradiological imaging findings,
the syndrome is mostly diagnosed based on the clinical findings.
Probably due to the latter factor, there is almost no major paper in the
literature concerning the neuroradiologic aspects of the syndrome.
Although our patient series is very limited for statistical evaluation,
broader series might put forward additional benefit of perfusion MR
imaging in diagnosis of pseudotumor cerebri |
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| ISSN: | 1301-062X 1309-2545 |