Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted Polymers
Development of an efficient technique for accurate and sensitive dibutyl phthalate (DBP) determination is crucial for food safety and environment protection. An ultrasensitive molecularly imprinted polymers (MIP) voltammetric sensor was herein engineered for the specific determination of DBP using p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/14/3/121 |
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| author | Chuanxiang Zhang Song Li Lingxiao Tang Shuo Li Changchun Hu Dan Zhang Long Chao Xueying Liu Yimin Tan Yan Deng |
| author_facet | Chuanxiang Zhang Song Li Lingxiao Tang Shuo Li Changchun Hu Dan Zhang Long Chao Xueying Liu Yimin Tan Yan Deng |
| author_sort | Chuanxiang Zhang |
| collection | DOAJ |
| description | Development of an efficient technique for accurate and sensitive dibutyl phthalate (DBP) determination is crucial for food safety and environment protection. An ultrasensitive molecularly imprinted polymers (MIP) voltammetric sensor was herein engineered for the specific determination of DBP using poly-<span style="font-variant: small-caps;">l</span>-lysine/poly(3,4-ethylenedioxythiophene)/porous graphene nanocomposite (PLL/PEDOT−PG) and poly(o-phenylenediamine)-imprinted film as a label-free and sensing platform. Fabrication of PEDOT−PG nanocomposites was achieved through a simple liquid–liquid interfacial polymerization. Subsequently, poly-<span style="font-variant: small-caps;">l</span>-lysine (PLL) functionalization was employed to enhance the dispersibility and stability of the prepared PEDOT−PG, as well as promote its adhesion on the sensor surface. In the presence of DBP, the imprinted poly(o-phenylenediamine) film was formed on the surface of PLL/PEDOT−PG. Investigation of the physical properties and electrochemical behavior of the MIP/PLL/PEDOT−PG indicates that the incorporation of PG into PEDOT, with PLL uniformly wrapping its surface, significantly enhanced conductivity, carrier mobility, stability, and provided a larger surface area for specific recognition sites. Under optimal experimental conditions, the electrochemical response exhibited a linear relationship with a logarithm of DBP concentration within the range of 1 fM to 5 µM, with the detection limit as low as 0.88 fM. The method demonstrated exceptional stability and repeatability and has been successfully applied to quantify DBP in plastic packaging materials. |
| first_indexed | 2024-04-24T18:29:49Z |
| format | Article |
| id | doaj.art-24f1a63365744cc6adcf4ae68676b756 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-04-24T18:29:49Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-24f1a63365744cc6adcf4ae68676b7562024-03-27T13:28:11ZengMDPI AGBiosensors2079-63742024-02-0114312110.3390/bios14030121Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted PolymersChuanxiang Zhang0Song Li1Lingxiao Tang2Shuo Li3Changchun Hu4Dan Zhang5Long Chao6Xueying Liu7Yimin Tan8Yan Deng9College of Packing and Materials Engineering, Hunan University of Technology, Zhuzhou 412007, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, ChinaCollege of Packing and Materials Engineering, Hunan University of Technology, Zhuzhou 412007, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, ChinaCollege of Packing and Materials Engineering, Hunan University of Technology, Zhuzhou 412007, ChinaHunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, ChinaDevelopment of an efficient technique for accurate and sensitive dibutyl phthalate (DBP) determination is crucial for food safety and environment protection. An ultrasensitive molecularly imprinted polymers (MIP) voltammetric sensor was herein engineered for the specific determination of DBP using poly-<span style="font-variant: small-caps;">l</span>-lysine/poly(3,4-ethylenedioxythiophene)/porous graphene nanocomposite (PLL/PEDOT−PG) and poly(o-phenylenediamine)-imprinted film as a label-free and sensing platform. Fabrication of PEDOT−PG nanocomposites was achieved through a simple liquid–liquid interfacial polymerization. Subsequently, poly-<span style="font-variant: small-caps;">l</span>-lysine (PLL) functionalization was employed to enhance the dispersibility and stability of the prepared PEDOT−PG, as well as promote its adhesion on the sensor surface. In the presence of DBP, the imprinted poly(o-phenylenediamine) film was formed on the surface of PLL/PEDOT−PG. Investigation of the physical properties and electrochemical behavior of the MIP/PLL/PEDOT−PG indicates that the incorporation of PG into PEDOT, with PLL uniformly wrapping its surface, significantly enhanced conductivity, carrier mobility, stability, and provided a larger surface area for specific recognition sites. Under optimal experimental conditions, the electrochemical response exhibited a linear relationship with a logarithm of DBP concentration within the range of 1 fM to 5 µM, with the detection limit as low as 0.88 fM. The method demonstrated exceptional stability and repeatability and has been successfully applied to quantify DBP in plastic packaging materials.https://www.mdpi.com/2079-6374/14/3/121molecular imprinting polymers (MIP)poly(3,4-ethylenedioxythiophene)porous grapheneelectrochemical sensordibutyl phthalate |
| spellingShingle | Chuanxiang Zhang Song Li Lingxiao Tang Shuo Li Changchun Hu Dan Zhang Long Chao Xueying Liu Yimin Tan Yan Deng Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted Polymers Biosensors molecular imprinting polymers (MIP) poly(3,4-ethylenedioxythiophene) porous graphene electrochemical sensor dibutyl phthalate |
| title | Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted Polymers |
| title_full | Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted Polymers |
| title_fullStr | Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted Polymers |
| title_full_unstemmed | Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted Polymers |
| title_short | Ultrasensitive, Label-Free Voltammetric Detection of Dibutyl Phthalate Based on Poly-<span style="font-variant: small-caps">l</span>-lysine/poly(3,4-ethylenedioxythiophene)-porous Graphene Nanocomposite and Molecularly Imprinted Polymers |
| title_sort | ultrasensitive label free voltammetric detection of dibutyl phthalate based on poly span style font variant small caps l span lysine poly 3 4 ethylenedioxythiophene porous graphene nanocomposite and molecularly imprinted polymers |
| topic | molecular imprinting polymers (MIP) poly(3,4-ethylenedioxythiophene) porous graphene electrochemical sensor dibutyl phthalate |
| url | https://www.mdpi.com/2079-6374/14/3/121 |
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