The Expanding Cell Diversity of the Brain Vasculature
The cerebrovasculature is essential to brain health and is tasked with ensuring adequate delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is coordinated through a dynamic, multi-directional cellular interplay between vascular, neuronal, and glial cells. Molecula...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.600767/full |
| _version_ | 1830482909452042240 |
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| author | Jayden M. Ross Jayden M. Ross Jayden M. Ross Jayden M. Ross Chang Kim Chang Kim Chang Kim Denise Allen Denise Allen Denise Allen Elizabeth E. Crouch Kazim Narsinh Daniel L. Cooke Adib A. Abla Tomasz J. Nowakowski Tomasz J. Nowakowski Tomasz J. Nowakowski Tomasz J. Nowakowski Ethan A. Winkler |
| author_facet | Jayden M. Ross Jayden M. Ross Jayden M. Ross Jayden M. Ross Chang Kim Chang Kim Chang Kim Denise Allen Denise Allen Denise Allen Elizabeth E. Crouch Kazim Narsinh Daniel L. Cooke Adib A. Abla Tomasz J. Nowakowski Tomasz J. Nowakowski Tomasz J. Nowakowski Tomasz J. Nowakowski Ethan A. Winkler |
| author_sort | Jayden M. Ross |
| collection | DOAJ |
| description | The cerebrovasculature is essential to brain health and is tasked with ensuring adequate delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is coordinated through a dynamic, multi-directional cellular interplay between vascular, neuronal, and glial cells. Molecular exchanges across the blood–brain barrier or the close matching of regional blood flow with brain activation are not uniformly assigned to arteries, capillaries, and veins. Evidence has supported functional segmentation of the brain vasculature. This is achieved in part through morphologic or transcriptional heterogeneity of brain vascular cells—including endothelium, pericytes, and vascular smooth muscle. Advances with single cell genomic technologies have shown increasing cell complexity of the brain vasculature identifying previously unknown cell types and further subclassifying transcriptional diversity in cardinal vascular cell types. Cell-type specific molecular transitions or zonations have been identified. In this review, we summarize emerging evidence for the expanding vascular cell diversity in the brain and how this may provide a cellular basis for functional segmentation along the arterial-venous axis. |
| first_indexed | 2024-12-21T17:43:18Z |
| format | Article |
| id | doaj.art-24f1f429414942c3b2fe1a40b3afd303 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T17:43:18Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-24f1f429414942c3b2fe1a40b3afd3032022-12-21T18:55:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-12-011110.3389/fphys.2020.600767600767The Expanding Cell Diversity of the Brain VasculatureJayden M. Ross0Jayden M. Ross1Jayden M. Ross2Jayden M. Ross3Chang Kim4Chang Kim5Chang Kim6Denise Allen7Denise Allen8Denise Allen9Elizabeth E. Crouch10Kazim Narsinh11Daniel L. Cooke12Adib A. Abla13Tomasz J. Nowakowski14Tomasz J. Nowakowski15Tomasz J. Nowakowski16Tomasz J. Nowakowski17Ethan A. Winkler18Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United StatesThe Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United StatesThe Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United StatesThe Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United StatesThe Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United StatesThe cerebrovasculature is essential to brain health and is tasked with ensuring adequate delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is coordinated through a dynamic, multi-directional cellular interplay between vascular, neuronal, and glial cells. Molecular exchanges across the blood–brain barrier or the close matching of regional blood flow with brain activation are not uniformly assigned to arteries, capillaries, and veins. Evidence has supported functional segmentation of the brain vasculature. This is achieved in part through morphologic or transcriptional heterogeneity of brain vascular cells—including endothelium, pericytes, and vascular smooth muscle. Advances with single cell genomic technologies have shown increasing cell complexity of the brain vasculature identifying previously unknown cell types and further subclassifying transcriptional diversity in cardinal vascular cell types. Cell-type specific molecular transitions or zonations have been identified. In this review, we summarize emerging evidence for the expanding vascular cell diversity in the brain and how this may provide a cellular basis for functional segmentation along the arterial-venous axis.https://www.frontiersin.org/articles/10.3389/fphys.2020.600767/fullneurovascular unitsingle cell sequencingendothelial cellspericytes and vascular smooth muscle cellsperivascular macrophagesperivascular fibroblasts |
| spellingShingle | Jayden M. Ross Jayden M. Ross Jayden M. Ross Jayden M. Ross Chang Kim Chang Kim Chang Kim Denise Allen Denise Allen Denise Allen Elizabeth E. Crouch Kazim Narsinh Daniel L. Cooke Adib A. Abla Tomasz J. Nowakowski Tomasz J. Nowakowski Tomasz J. Nowakowski Tomasz J. Nowakowski Ethan A. Winkler The Expanding Cell Diversity of the Brain Vasculature Frontiers in Physiology neurovascular unit single cell sequencing endothelial cells pericytes and vascular smooth muscle cells perivascular macrophages perivascular fibroblasts |
| title | The Expanding Cell Diversity of the Brain Vasculature |
| title_full | The Expanding Cell Diversity of the Brain Vasculature |
| title_fullStr | The Expanding Cell Diversity of the Brain Vasculature |
| title_full_unstemmed | The Expanding Cell Diversity of the Brain Vasculature |
| title_short | The Expanding Cell Diversity of the Brain Vasculature |
| title_sort | expanding cell diversity of the brain vasculature |
| topic | neurovascular unit single cell sequencing endothelial cells pericytes and vascular smooth muscle cells perivascular macrophages perivascular fibroblasts |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2020.600767/full |
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