No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington’s disease

No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington’s disease

Abstract Prominent features of HD neuropathology are the intranuclear and cytoplasmic inclusions of huntingtin and striatal and cortical neuronal cell death. Recently, synaptic defects have been reported on HD-related studies, including impairment of neurotransmitter release and alterations of synap...

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Bibliographic Details
Main Authors: Ting-Ting Huang, Ruben Smith, Karl Bacos, Dong-Yan Song, Richard M. Faull, Henry J. Waldvogel, Jia-Yi Li
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Acta Neuropathologica Communications
Subjects:
Huntington’s disease
Active zone proteins
Synaptic dysfunction
Protein aggregation
Online Access:http://link.springer.com/article/10.1186/s40478-020-00949-y

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